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CASP8 [cytosol]
Stable Identifier
R-GGA-57031
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
CASP8(1-479), F1NXP6
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF(TICAM1)-mediated TLR4 signaling (Gallus gallus)
TRIF-mediated programmed cell death (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TLR4-induced ripoptosome assembly (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
Caspase-8 processing within TLR4 complex (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
Dimerization of procaspase-8 (Gallus gallus)
FAS-mediated dimerization of procaspase-8 (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Gallus gallus)
procaspase-8 dimer [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Gallus gallus)
procaspase-8 dimer [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Gallus gallus)
procaspase-8 dimer [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
Regulation by c-FLIP (Gallus gallus)
Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
CASP8 activity is inhibited (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signalling (Gallus gallus)
FasL/ CD95L signaling (Gallus gallus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TRAIL signaling (Gallus gallus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
CASP8 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NXP6
Gene Names
CASP8
Reference Genes
ENSEMBL:ENSGALG00000008355
Reference Transcript
RefSeq:XM_015289376.1 CASP8
RefSeq:XM_015289375.1 CASP8
RefSeq:XM_015289374.1 CASP8
Other Identifiers
395284
GO:0002376
GO:0003674
GO:0004197
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0007165
GO:0008150
GO:0008219
GO:0008233
GO:0008234
GO:0009056
GO:0019899
GO:0030154
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097202
GO:0097342
GT_A_87_P035289
GT_A_87_P193368
Gga.2451.1.S1_at
Participates
as an input of
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
FAS-mediated dimerization of procaspase-8 (Gallus gallus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)
TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
TLR4-induced ripoptosome assembly (Gallus gallus)
as a component of
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Gallus gallus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Gallus gallus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
DISC:procaspase-8 [plasma membrane] (Gallus gallus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Gallus gallus)
procaspase-8 dimer [cytosol] (Gallus gallus)
Other forms of this molecule
CASP8 [cytosol]
CASP8 [mitochondrial outer membrane]
CASP8 [mitochondrial outer membrane]
CASP8 [cytosol]
CASP8 [cytosol]
Inferred From
CASP8(1-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015144862.1
,
XP_015144861.1
,
XP_015144860.1
OpenTargets
ENSG00000064012
Ensembl
ENSGALT00000013606
,
ENSGALG00000008355
,
ENSGALP00000013591
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