IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex

Stable Identifier
R-GGA-571324
Type
Reaction [binding]
Species
Gallus gallus
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex
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In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.

Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
19539094 The avian Toll-Like receptor pathway--subtle differences amidst general conformity

Cormican, P, Lloyd, AT, Downing, T, Connell, SJ, Bradley, D, O'Farrelly, C

Dev Comp Immunol 2009
Participants
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Output
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as an event of
Inferred From
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
Authored
Shamovsky, V  (2010-04-02)
Reviewed
D'Eustachio, P  (2010-12-06)
Created
Shamovsky, V  (2010-04-09)
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