Activated TRAF6 synthesizes free K63 linked pUb chains.

Stable Identifier
R-GGA-573294
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of the TAK1 (TAB2 or TAB3), leading to the activation of TAK1[Xia et al. 2009].
Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Xu, M, Adhikari, A, Chen, ZJ

Oncogene 2007
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Adhikari, A, Zeng, W, Chen, ZJ, Pineda, G, Sun, L, Chen, X, Jiang, X, Xia, ZP

Nature 2009
Participants
Participates
Event Information
Catalyst Activity

ubiquitin-ubiquitin ligase activity of oligo pUb-TRAF6 : p-IRAK2 [endosome membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!