Reactome | TRAF2 [cytosol]

TRAF2 [cytosol]

Stable Identifier

R-GGA-66370

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

TRAF2, A0A3Q2U6P9

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Gallus gallus)

- Apoptosis (Gallus gallus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Gallus gallus)
    - Caspase activation via Death Receptors in the presence of ligand (Gallus gallus)
      - Dimerization of procaspase-8 (Gallus gallus)
        
        TNF-mediated dimerization of procaspase-8 (Gallus gallus)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
      - Regulation by c-FLIP (Gallus gallus)
        
        Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Gallus gallus)
        
        TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
- Regulated Necrosis (Gallus gallus)
  - RIPK1-mediated regulated necrosis (Gallus gallus)
    - Regulation of necroptotic cell death (Gallus gallus)
      - CASP8 activity is inhibited (Gallus gallus)
        
        FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Gallus gallus)
        
        DISC:procaspase-8 [plasma membrane] (Gallus gallus)
        
        DISC [plasma membrane] (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
      - RIPK1 is cleaved by CASP8 (Gallus gallus)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)
        
        TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Gallus gallus)
        
        TRAF2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2U6P9

Gene Names

TRAF2

Reference Genes

BioGPS Gene:417287 TRAF2

ENSEMBL:ENSGALG00000042838

Monarch:417287 TRAF2

NCBI Gene:417287 TRAF2

Reference Transcript

RefSeq:XM_015279623.1 TRAF2

Other Identifiers

417287

GO:0000151

GO:0002376

GO:0002637

GO:0002726

GO:0002947

GO:0003674

GO:0004842

GO:0005164

GO:0005174

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006464

GO:0006950

GO:0007165

GO:0007250

GO:0008150

GO:0008219

GO:0008270

GO:0008289

GO:0009056

GO:0009058

GO:0009898

GO:0012506

GO:0019899

GO:0019901

GO:0019903

GO:0022607

GO:0023019

GO:0030163

GO:0030674

GO:0031625

GO:0031996

GO:0032743

GO:0032991

GO:0033209

GO:0034622

GO:0034641

GO:0034655

GO:0035631

GO:0042802

GO:0042981

GO:0043120

GO:0043123

GO:0043167

GO:0043226

GO:0043254

GO:0043507

GO:0044877

GO:0045121

GO:0046328

GO:0046625

GO:0046872

GO:0048255

GO:0051091

GO:0051092

GO:0051865

GO:0065003

GO:0070534

GO:0071732

GO:0097057

GO:0097300

GO:0097400

GO:1903265

GO:1903721

GO:1990604

GO:2001238

GT_A_87_P027663

GT_A_87_P114088

GgaAffx.22768.1.S1_s_at

Participates

as a member of

as a component of

Other forms of this molecule

TRAF2 [nucleoplasm]

TRAF2 [cytosol]

Inferred From

TRAF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015135109.1

OpenTargets

ENSG00000127191

Ensembl

ENSGALG00000042838, ENSGALT00000093573, ENSGALP00000070161

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