Reactome | RPS27A [cytosol]

RPS27A [cytosol]

Stable Identifier

R-GGA-72363

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

RPS27A(77-156), P79781

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Gallus gallus)

- Nonsense-Mediated Decay (NMD) (Gallus gallus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Gallus gallus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS27A [cytosol] (Gallus gallus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS27A [cytosol] (Gallus gallus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS27A [cytosol] (Gallus gallus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Gallus gallus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS27A [cytosol] (Gallus gallus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Gallus gallus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Gallus gallus)
        
        80S ribosome [cytosol] (Gallus gallus)
        
        40S ribosomal complex [cytosol] (Gallus gallus)
        
        RPS27A [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:P79781 RPS27A

Gene Names

RPS27A, UBA80

Chain

chain:1-76, chain:77-156

Reference Genes

BioGPS Gene:395796 UBIQ

KEGG:gga:395796 UBIQ

Monarch:395796 UBIQ

NCBI Gene:395796 UBIQ

UCSC:P79781 RPS27A

Reference Transcript

Participates

as an output of

UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Gallus gallus)

as a component of

40S ribosomal complex [cytosol] (Gallus gallus)

Other forms of this molecule

K63-ubiquitin (RPS27A) [cytosol]

ubiquitin (RPS27A) [cytosol]

K48-ubiquitin (RPS27A) [cytosol]

RPS27A [nucleoplasm]

ubiquitin (RPS27A) [nucleoplasm]

RPS27A [cytosol]

RPS27A [nucleoplasm]

K63-ubiquitin (RPS27A) [plasma membrane]

K63-ubiquitin (RPS27A) [endosome membrane]

K63-ubiquitin (RPS27A) [mitochondrial outer membrane]

RPS27A [cytosol]

RPS27A [endosome membrane]

phospho-RPS27A [cytosol]

RPS27A [cytosol]

phospho-RPS27A [nucleoplasm]

RPS27A [cytosol]

RPS27A [mitochondrial outer membrane]

K48-ubiquitin (RPS27A) [mitochondrial outer membrane]

RPS27A [mitochondrial outer membrane]

RPS27A [nucleoplasm]

RPS27A [endocytic vesicle membrane]

Inferred From

RPS27A(77-156) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_990284.1, NP_001274134.1

PRO

P79781

PDB

8Q7Z, 6ZVK, 8Q87