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PI3K [cytosol]
Stable Identifier
R-GGA-74693
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Cell surface interactions at the vascular wall (Gallus gallus)
Tie2 Signaling (Gallus gallus)
Interaction of Tie2 and p85 of PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p85 bound to Tie2 [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K bound to TRAT [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Recruitment of PI3K to plasma membrane (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K bound to TRAT [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
Role of LAT2/NTAL/LAB on calcium mobilization (Gallus gallus)
PI3K associates with phosphorylated GAB2 (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
PI3K binds to p-6Y-SYK (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K bound to TRAT [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K bound to TRAT [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS:GTP binds PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p21 RAS:GTP:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
Active ALK recruits PI3K (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by LTK (Gallus gallus)
Active LTK receptor binds PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
PI3K/AKT activation (Gallus gallus)
Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
PI3-kinase binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
p-AXL binds PI3K (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
PI3K [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-catalytic subunit [cytosol]
(Gallus gallus)
PI3K-regulatory subunit [cytosol]
(Gallus gallus)
Participates
as an input of
Active ALK recruits PI3K (Gallus gallus)
Active LTK receptor binds PI3K (Gallus gallus)
Interaction of Tie2 and p85 of PI3K (Gallus gallus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
RAS:GTP binds PI3K (Gallus gallus)
PI3K associates with phosphorylated GAB2 (Gallus gallus)
p-AXL binds PI3K (Gallus gallus)
PI3-kinase binds to the active receptor (Gallus gallus)
Recruitment of PI3K to plasma membrane (Gallus gallus)
PI3K binds to p-6Y-SYK (Gallus gallus)
Active IRS recruits PI3K to the plasma membrane and activates it (Gallus gallus)
as a component of
Active ALK:PI3K [plasma membrane] (Gallus gallus)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Gallus gallus)
p85 bound to Tie2 [plasma membrane] (Gallus gallus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Gallus gallus)
p21 RAS:GTP:PI3K [plasma membrane] (Gallus gallus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Gallus gallus)
PI3K:p-6Y-SYK [plasma membrane] (Gallus gallus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
PI3K bound to TRAT [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Gallus gallus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Gallus gallus)
Inferred From
PI3K [cytosol]
(Homo sapiens)
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