Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
LOC107051846 [cytosol]
Stable Identifier
R-GGA-74769
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
IRS1, A0A8V0ZNF9
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-7 signaling (Gallus gallus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Gallus gallus)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Gallus gallus)
IRS1,2 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
IRS1,2 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
Active ALK dimer binds IRS1 (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Active ALK phosphorylates IRS1 (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS activation (Gallus gallus)
Binding of IRS to insulin receptor (Gallus gallus)
IRS1,2 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Gallus gallus)
IRS1,2 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Phosphorylation of IRS (Gallus gallus)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Gallus gallus)
IRS1,2 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Signaling by LTK (Gallus gallus)
Active LTK binds IRS1 (Gallus gallus)
Active LTK:IRS1 [plasma membrane] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
Active LTK phosphorylates IRS1 (Gallus gallus)
Active LTK:IRS1 [plasma membrane] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
IRS1 recruits GRB2 to active LTK (Gallus gallus)
Active LTK:p-Y IRS1:GRB2 [plasma membrane] (Gallus gallus)
LOC107051846 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0ZNF9
Gene Names
LOC107051846
Reference Genes
BioGPS Gene:107051846 LOC107051846
ENSEMBL:ENSGALG00010023620.1
Monarch:107051846 LOC107051846
NCBI Gene:107051846 LOC107051846
UCSC:A0A8V0ZNF9 LOC107051846
Reference Transcript
RefSeq:XM_015277004.4 LOC107051846
Other Identifiers
107051846
GO:0001784
GO:0005102
GO:0005158
GO:0005159
GO:0005654
GO:0005829
GO:0005886
GO:0005901
GO:0007165
GO:0008286
GO:0009967
GO:0010907
GO:0019221
GO:0030159
GO:0032000
GO:0032868
GO:0032869
GO:0035591
GO:0043491
GO:0043548
GO:0045725
GO:0046326
GO:0046628
GO:0046676
GO:0048009
GO:0060090
GT_A_87_P077281
GgaAffx.3088.1.S1_at
Participates
as an input of
Active ALK dimer binds IRS1 (Gallus gallus)
Active LTK binds IRS1 (Gallus gallus)
as a component of
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
Active LTK:p-Y IRS1:GRB2 [plasma membrane] (Gallus gallus)
Active LTK:IRS1 [plasma membrane] (Gallus gallus)
as a member of
IRS1,2 [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-LOC107051846 [plasma membrane]
LOC107051846 [plasma membrane]
phospho-LOC107051846 [cytosol]
phospho-LOC107051846 [plasma membrane]
Inferred From
IRS1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015132490.2
ENSEMBL
ENSGALT00010057511
,
ENSGALP00010034944
,
ENSGALP00010034941
,
ENSGALG00010023620
,
ENSGALT00010057507
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text