Reactome | EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane]

EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane]

Stable Identifier

R-GGA-8866261

Type

Complex

Species

Gallus gallus

Compartment

plasma membrane

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an output of

Epsin family proteins bind ubiquitinated cargo (Gallus gallus)

as a member of

CLASP proteins:cargo [plasma membrane] (Gallus gallus)

Inferred From

EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)

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