Reactome | GAK [cytosol]

GAK [cytosol]

Stable Identifier

R-GGA-8868619

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

GAK, A0A8V0YRN4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        GAK,DNAJC6 [cytosol] (Gallus gallus)
        
        GAK [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0YRN4

Gene Names

GAK

Reference Genes

ENSEMBL:ENSGALG00010013313.1

UCSC:A0A8V0YRN4 GAK

Other Identifiers

427291

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005737

GO:0005794

GO:0005925

GO:0006468

GO:0006898

GO:0007030

GO:0010977

GO:0016192

GO:0016301

GO:0016740

GO:0030136

GO:0031410

GO:0031982

GO:0034067

GO:0043226

GO:0048268

GO:0048471

GO:0065003

GO:0070161

GO:0072318

GO:0072583

GO:0072659

GO:0090160

GO:0140096

GO:1905443

GT_A_87_P023021

GT_A_87_P092996

Gga.10527.1.S1_at

Gga.18805.1.S1_s_at

Participates

as a member of

GAK,DNAJC6 [cytosol] (Gallus gallus)

Other forms of this molecule

GAK [Golgi membrane]

GAK [cytoplasmic vesicle membrane]

Inferred From

GAK [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSGALT00010032041, ENSGALG00010013313, ENSGALP00010018831

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