Reactome | SCARB2 [clathrin-coated endocytic vesicle membrane]

SCARB2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-GGA-8869106

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SCARB2, E1BRR6

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        SCARB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1BRR6

Gene Names

SCARB2

Reference Genes

BioGPS Gene:422638 SCARB2

ENSEMBL:ENSGALG00000011499

ENSEMBL:ENSGALG00010004104.1 SCARB2

Monarch:422638 SCARB2

NCBI Gene:422638 SCARB2

Reference Transcript

RefSeq:XM_420593.5 SCARB2

Other Identifiers

422638

GO:0005044

GO:0005737

GO:0005764

GO:0005773

GO:0005886

GO:0005975

GO:0006622

GO:0006886

GO:0006898

GO:0016020

GO:0016192

GO:0019899

GO:0038024

GO:0042803

GO:0043226

GO:0043470

GT_A_87_P023883

GT_A_87_P095591

Gga.5283.1.S1_at

Participates

as a member of

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Other forms of this molecule

SCARB2 [plasma membrane]

Inferred From

SCARB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_420593.1

OpenTargets

ENSG00000138760

Ensembl

ENSGALG00010004104, ENSGALT00010009561, ENSGALP00010005623

PRO

E1BRR6

Cite Us!