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MyrG-SRC [plasma membrane]
Stable Identifier
R-GGA-8876922
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
P00523
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
ESR-associated SRC autophosphorylates (Gallus gallus)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Membrane estrogen receptors bind SRC (Gallus gallus)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
PXN:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK3 (TRKC) (Gallus gallus)
Activated NTRK3 signals through PI3K (Gallus gallus)
Activated NTRK3 binds SRC (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
Activation of Src (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
SH2 domain of Src binds to the active receptor (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
MyrG-SRC [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P00523 SRC
Gene Names
SRC
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:396442 SRC
KEGG:gga:396442 SRC
Monarch:396442 SRC
NCBI Gene:396442 SRC
UCSC:P00523 SRC
Reference Transcript
RefSeq:NM_205457.2 SRC
RefSeq:XM_015296348.1 SRC
Participates
as a component of
Integrin alphaIIb beta3:SRC [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Gallus gallus)
PXN:MyrG-SRC [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Gallus gallus)
as an input of
Membrane estrogen receptors bind SRC (Gallus gallus)
Activated NTRK3 binds SRC (Gallus gallus)
SH2 domain of Src binds to the active receptor (Gallus gallus)
Other forms of this molecule
SRC-2 [cytosol]
phospho-MyrG-p-Y419-SRC [plasma membrane]
SRC-1 [plasma membrane]
phospho-MyrG,p-Y530-SRC [plasma membrane]
phospho-p-Y419-SRC [cytosol]
Src [cytosol]
phospho-p-Y419-SRC [cytosol]
SRC [cytosol]
Inferred From
MyrG-SRC [plasma membrane]
(Homo sapiens)
Modified Residues
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
XP_015151834.1
,
NP_990788.2
ZINC - Investigational
SRC_CHICK
ZINC - World Drugs
SRC_CHICK
ZINC - FDA approved
SRC_CHICK
ZINC - Substances
SRC_CHICK
ZINC target
P00523
PRO
P00523
ZINC - Predictions - Purchasable
SRC_CHICK
PDB
4HVV
,
1P13
,
2QLQ
,
7A3A
,
7A36
,
4JZ4
,
4RTY
,
3EL8
,
3OF0
,
3F3T
,
3FJ5
,
7A37
,
4AGW
,
6HVE
,
3D7U
,
2HWO
,
1PRL
,
5D11
,
3LOK
,
6XVO
,
1RLQ
,
3EN4
,
5XP5
,
7NES
,
3U51
,
3QLG
,
5K9I
,
6L8L
,
2OIQ
,
4OMM
,
7A31
,
7PW0
,
7PVY
,
3DQX
,
1F2F
,
2QQ7
,
4OMQ
,
7D57
,
7A35
,
7A34
,
7A39
,
3OEZ
,
7AH3
,
5TEH
,
3TZ7
,
4FIC
,
4YBK
,
6XX2
,
7A3D
,
6HVF
,
3F3U
,
4JZ3
,
2QI8
,
6XVN
,
4U5J
,
5SWH
,
1RLP
,
5T0P
,
3EN5
,
5XP7
,
3QLF
,
5OB1
,
4RTU
,
4LGH
,
5OAV
,
3G6H
,
4QT7
,
5SYS
,
4OMN
,
7PVZ
,
3GEQ
,
7A30
,
5I11
,
4RTW
,
7A33
,
4HVW
,
4YBJ
,
5J5S
,
4O2P
,
3TZ8
,
4LE9
,
7A3C
,
4RTZ
,
6WIW
,
2HWP
,
5EC7
,
3F3V
,
6XX5
,
3UQG
,
5D10
,
1NLP
,
3UQF
,
3F6X
,
3EN6
,
7NET
,
3TZ9
,
5OB0
,
4LGG
,
3SVV
,
7PVX
,
4OMO
,
2PTK
,
1SRM
,
4RTV
,
7A3B
,
4HVU
,
4OMP
,
3G5D
,
4MCV
,
3EL7
,
7A3E
,
3DQW
,
4RTX
,
7WF5
,
7A38
,
6XX3
,
3D7T
,
6XX4
,
3U4W
,
3F3W
,
5D12
,
1F1W
,
1PRM
,
5BMM
,
5ECA
,
6XVM
,
1NLO
,
3EN7
,
7NER
,
4DGG
,
7D5O
,
5OB2
,
7PVW
,
7A32
,
4OML
,
3G6G
,
1SRL
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.719
7
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.59
4
UniProt:Q00944
11
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
PTK2 [cytosol]
(R-GGA-201621)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
0.589
3
UniProt:Q9QWY8-1 ASAP1
0.581
3
UniProt:O88703
1
HCN2 [plasma membrane]
(R-MMU-977502)
0.581
5
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.564
2
UniProt:Q90738 AFAP1
0.564
3
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.556
3
UniProt:Q9QWY8-2 ASAP1
0.544
2
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.544
2
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.525
2
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