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What is Reactome ?
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phospho-SHC1 [cytosol]
Stable Identifier
R-GGA-912321
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-Y349,Y350,Y427-SHC1, A0A1D5NYP8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
RET signaling (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
SHC1 in the RET complex is phosphorylated (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-5Y-RET complexes bind GRB2 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits SHIP (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Phosphorylated SHC1 recruits SHIP (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
SHC1 events in ERBB2 signaling (Gallus gallus)
Activated PKC phosphorylates SHC1 (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Signaling by LTK (Gallus gallus)
Active LTK receptor phosphorylates SHC1 (Gallus gallus)
Active LTK:p-3Y SHC1 [plasma membrane] (Gallus gallus)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Active LTK recruits GRB2:SOS1 (Gallus gallus)
Active LTK:p-3Y SHC1 [plasma membrane] (Gallus gallus)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
SHC-related events triggered by IGF1R (Gallus gallus)
GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
IGF1R phosphorylates SHC1 (Gallus gallus)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
phospho-SHC1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5NYP8
Gene Names
SHC1
Reference Genes
BioGPS Gene:395934 SHC1
ENSEMBL:ENSGALG00000039775
ENSEMBL:ENSGALG00010027922.1 SHC1
KEGG Gene (Gallus gallus):395934 SHC1
Monarch:395934 SHC1
NCBI Gene:395934 SHC1
Reference Transcript
RefSeq:NM_001293280.2 SHC1
Other Identifiers
395934
GO:0001525
GO:0001784
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005886
GO:0006351
GO:0006355
GO:0007010
GO:0007155
GO:0007173
GO:0007507
GO:0008286
GO:0012501
GO:0023052
GO:0030036
GO:0030971
GO:0035556
GO:0042127
GO:0042742
GO:0043066
GO:0043410
GO:0045892
GO:0045893
GO:0046875
GO:0048009
GO:0048408
GO:0048856
GO:0060090
GO:0070374
GO:0071363
GO:0098542
GO:0098609
GO:0110165
GT_A_87_P037982
GT_A_87_P088641
Gga.2219.1.S1_at
GgaAffx.8748.1.S1_at
Participates
as a candidate of
p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Gallus gallus)
as a component of
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Gallus gallus)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Gallus gallus)
as an input of
GRB2-1:SOS1 binds p-3Y-SHC1 (Gallus gallus)
Activated PKC phosphorylates SHC1 (Gallus gallus)
as an output of
p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)
Other forms of this molecule
SHC1 [plasma membrane]
SHC1 [plasma membrane]
SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
SHC1 [cytosol]
SHC1 [cytosol]
SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
Inferred From
p-3Y-SHC1 [cytosol]
(Homo sapiens)
p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol]
(Homo sapiens)
p-Y349,Y350,Y427-SHC1-1 [cytosol]
(Homo sapiens)
p-Y349,Y350,Y427-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 427 (in Homo sapiens)
Coordinate
427
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 349 (in Homo sapiens)
Coordinate
349
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
Coordinate
350
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001280209.1
OpenTargets
ENSG00000160691
Ensembl
ENSGALT00010067680
,
ENSGALG00010027922
,
ENSGALP00010041423
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