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Cbl binds B-cell linker protein
Stable Identifier
R-GGA-912730
Type
Reaction [binding]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
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SBGN
Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
10684856
Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding
Yamamoto, T
,
Hironaka, K
,
Kurosaki, M
,
Maeda, A
,
Tezuka, T
,
Kurosaki, T
,
Yasuda, T
J Exp Med
2000
Participants
Input
B-cell linker protein [cytosol]
(Gallus gallus)
p(Y684,728,773)-Cbl [cytosol]
(Gallus gallus)
Output
B-cell linker protein:p(Y684,728,773)-Cbl [cytosol]
(Gallus gallus)
Orthologous Events
CBL binds B-cell linker protein (Homo sapiens)
Authored
Ray, KP (2010-05-17)
Created
Jupe, S (2010-07-13)
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