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EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-GGA-9624425
Type
Complex
Species
Gallus gallus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
RAS GEFs [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
PTK2 autophosphorylates downstream of EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
PTK2 binds activated EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
EGFR autophosphorylation (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGFR downregulation (Gallus gallus)
Binding of CBL to EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
CBL ubiquitinates Sprouty (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Localization of CBL:GRB2 to the membrane (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Phosphorylation of CBL (EGFR:CBL) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGFR interacts with phospholipase C-gamma (Gallus gallus)
Active PLC-gamma1 dissociates from EGFR (Gallus gallus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
GAB1 signalosome (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Dephosphorylation of PAG by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
GAB1 phosphorylation by EGFR kinase (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
GRB2 events in EGFR signaling (Gallus gallus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
Phosphorylation of EGFR by SRC kinase (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SHC1 events in EGFR signaling (Gallus gallus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Gallus gallus)
x 2
phospho-EGFR [plasma membrane]
(Gallus gallus)
Participates
as an input of
PTK2 binds activated EGFR (Gallus gallus)
Localization of CBL:GRB2 to the membrane (Gallus gallus)
Binding of CBL to EGFR (Gallus gallus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Gallus gallus)
GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)
as a component of
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Gallus gallus)
as an output of
Active PLC-gamma1 dissociates from EGFR (Gallus gallus)
Phosphorylation of EGFR by SRC kinase (Gallus gallus)
EGFR autophosphorylation (Gallus gallus)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
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