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OPTN [cytosol]
Stable Identifier
R-GGA-9687907
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
OPTN, A0A8V0XR54
Locations in the PathwayBrowser
Expand all
Autophagy (Gallus gallus)
Macroautophagy (Gallus gallus)
Selective autophagy (Gallus gallus)
Mitophagy (Gallus gallus)
PINK1-PRKN Mediated Mitophagy (Gallus gallus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Gallus gallus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
p-S-TBK1 phosphorylates OPTN (Gallus gallus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Gallus gallus)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Gallus gallus)
OPTN binds TBK1 within the activated TLR4 complex (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
TBK1 is phosphorylated within the activated TLR4 complex (Gallus gallus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
OPTN binds CASP8 (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
OPTN:CASP8 [cytosol] (Gallus gallus)
OPTN [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0XR54
Gene Names
OPTN
Reference Genes
BioGPS Gene:374079 OPTN
ENSEMBL:ENSGALG00010005383.1
Monarch:374079 OPTN
NCBI Gene:374079 OPTN
UCSC:A0A8V0XR54 OPTN
Reference Transcript
RefSeq:NM_001396095.1 OPTN
RefSeq:NM_001396097.1 OPTN
RefSeq:NM_001396096.1 OPTN
RefSeq:XM_046940964.1 OPTN
Other Identifiers
374079
GO:0001920
GO:0005634
GO:0005737
GO:0005768
GO:0005773
GO:0005776
GO:0005794
GO:0005802
GO:0005829
GO:0006914
GO:0007030
GO:0008104
GO:0008270
GO:0010508
GO:0016192
GO:0030674
GO:0031410
GO:0031593
GO:0034067
GO:0034620
GO:0042802
GO:0043001
GO:0043122
GO:0043124
GO:0046872
GO:0048471
GO:0050829
GO:0055037
GO:0060090
GO:0061734
GO:0070530
GO:0072659
GO:0090161
GO:0098542
GO:1904417
Gga.4189.1.S1_s_at
Participates
as an input of
OPTN binds CASP8 (Gallus gallus)
OPTN binds TBK1 within the activated TLR4 complex (Gallus gallus)
OPTN, TBK1 bind ubiquitinated MOM proteins (Gallus gallus)
as a component of
OPTN:CASP8 [cytosol] (Gallus gallus)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Gallus gallus)
TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol] (Gallus gallus)
p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Gallus gallus)
Other forms of this molecule
OPTN [recycling endosome membrane]
phospho-OPTN [nucleoplasm]
phospho-OPTN [cytosol]
OPTN [Golgi membrane]
phospho-OPTN [cytosol]
Inferred From
OPTN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001383025.1
,
NP_001383024.1
,
NP_001383026.1
,
XP_046796920.1
ENSEMBL
ENSGALT00010012817
,
ENSGALP00010007380
,
ENSGALG00010005383
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