Reactome | K63-ubiquitin (UBB 1) [plasma membrane]

K63-ubiquitin (UBB 1) [plasma membrane]

Stable Identifier

R-GGA-975697

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR15 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - NFkB activation mediated by RIP1 complexed with activated TLR3 (Gallus gallus)
      - chicken RIP1 facilitates IKKs complex activation (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
    - TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
      - MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
      - TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR5 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Auto ubiquitination of oligo TRAF6 bound to p-IRAK2 (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex (Gallus gallus)
        
        p-IRAK2:pUb oligo TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        Activated TAK1 mediates p38 MAP kinase phosphorylation (Gallus gallus)
        
        Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)
        
        TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Gallus gallus)
        
        Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)
        
        Activated chicken TAK1 complexes [cytosol] (Gallus gallus)
        
        p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [plasma membrane] (Gallus gallus)
        
        pUb oligo TRAF6 : p-IRAK2 [plasma membrane] (Gallus gallus)
        
        K63 linked pUb TRAF6 [plasma membrane] (Gallus gallus)
        
        K63 polyubiquitin chain [plasma membrane] (Gallus gallus)
        
        K63_Ubiquitin [plasma membrane] (Gallus gallus)
        
        K63-ubiquitin (UBB 1) [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:P0CG62 UBB

Gene Names

UBB

Chain

chain:1-76, chain:77-152, chain:153-228, chain:229-304, propeptide:-

Reference Genes

BioGPS Gene:101747587 UBB

ENSEMBL:ENSGALG00000004509 UBB

Monarch:101747587 UBB

NCBI Gene:101747587 UBB

Reference Transcript

RefSeq:XM_004946664.2 UBB

Other Identifiers

101747587

GO:0000003

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006259

GO:0006281

GO:0006464

GO:0006950

GO:0007049

GO:0007141

GO:0007144

GO:0008150

GO:0008584

GO:0008585

GO:0009056

GO:0016567

GO:0019899

GO:0019941

GO:0021888

GO:0022627

GO:0030154

GO:0031386

GO:0031625

GO:0032991

GO:0034641

GO:0042592

GO:0043226

GO:0048856

GO:0060612

GO:0060613

GO:0072520

GO:0097009

GT_A_87_P066561

GT_A_87_P066576

GT_A_87_P066591

GT_A_87_P066596

GT_A_87_P131103

GT_Xhyb_Chicken_CN216923_456

GT_Xhyb_Chicken_CN224619_2993

Gga.4421.1.S1_a_at

Gga.4421.2.S1_x_at

Gga.4421.3.S1_x_at

Participates

as a member of

K63_Ubiquitin [plasma membrane] (Gallus gallus)

Other forms of this molecule

UBB [mitochondrial outer membrane]

K48-ubiquitin (UBB 2) [mitochondrial outer membrane]

UBB [mitochondrial outer membrane]

K48-ubiquitin (UBB 1) [mitochondrial outer membrane]

UBB [mitochondrial outer membrane]

K48-ubiquitin (UBB 3) [mitochondrial outer membrane]

UBB [mitochondrial outer membrane]

K48-ubiquitin (UBB 4) [mitochondrial outer membrane]

UBB [mitochondrial outer membrane]

UBB [cytosol]

phospho-UBB [nucleoplasm]

UBB [cytosol]

phospho-UBB [cytosol]

UBB [endosome membrane]

K63-ubiquitin (UBB 3) [mitochondrial outer membrane]

K63-ubiquitin (UBB 4) [mitochondrial outer membrane]

K63-ubiquitin (UBB 2) [mitochondrial outer membrane]

K63-ubiquitin (UBB 1) [mitochondrial outer membrane]

K63-ubiquitin (UBB 1) [endosome membrane]

K63-ubiquitin (UBB 2) [endosome membrane]

K63-ubiquitin (UBB 4) [endosome membrane]

K63-ubiquitin (UBB 3) [endosome membrane]

K63-ubiquitin (UBB 4) [plasma membrane]

K63-ubiquitin (UBB 2) [plasma membrane]

K63-ubiquitin (UBB 3) [plasma membrane]

UBB [cytosol]

UBB [nucleoplasm]

UBB [cytosol]

UBB [nucleoplasm]

ubiquitin (UBB 4) [nucleoplasm]

UBB [nucleoplasm]

ubiquitin (UBB 2) [nucleoplasm]

UBB [nucleoplasm]

ubiquitin (UBB 1) [nucleoplasm]

ubiquitin (UBB 3) [nucleoplasm]

UBB [nucleoplasm]

K48-ubiquitin (UBB 1) [cytosol]

UBB [cytosol]

K63-ubiquitin (UBB 1) [cytosol]

UBB [cytosol]

K63-ubiquitin (UBB 4) [cytosol]

UBB [cytosol]

K63-ubiquitin (UBB 2) [cytosol]

K63-ubiquitin (UBB 3) [cytosol]

UBB [cytosol]

ubiquitin (UBB 2) [cytosol]

UBB [cytosol]

ubiquitin (UBB 3) [cytosol]

ubiquitin (UBB 4) [cytosol]

UBB [cytosol]

ubiquitin (UBB 1) [cytosol]

UBB [cytosol]

K48-ubiquitin (UBB 3) [cytosol]

K48-ubiquitin (UBB 2) [cytosol]

K48-ubiquitin (UBB 4) [cytosol]

Modified Residues

Name

ubiquitinylated lysine at 63

Coordinate

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_004946721.1

OpenTargets

ENSG00000170315

Ensembl

ENSGALP00000053353, ENSGALG00000004509, ENSGALT00000061244

PRO

P0CG62

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