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PLCG2 [cytosol]
Stable Identifier
R-GGA-984806
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
PLCG2, A0A1D5PHP4
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
BTK binds BTK inhibitors (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
BTK:BTK inhibitors [plasma membrane] (Gallus gallus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Gallus gallus)
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
Activation of RAC1 by VAV2/3 (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Phosphorylation of BTK by p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-SYK/p-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Autophosphorylation of BTK/ITK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Activation of RAC1 by VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Autophosphorylation of PAK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of VAV to p-SLP-76 (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
Phosphorylation and activation of PLCG (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Recruitment of PLCgamma to membrane (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Gallus gallus)
PLC gamma1,2 [cytosol] (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)
PLCG2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1D5PHP4
Gene Names
PLCG2
Reference Genes
BioGPS Gene:415805 PLCG2
ENSEMBL:ENSGALG00000033507
ENSEMBL:ENSGALG00010007393.1 PLCG2
KEGG Gene (Gallus gallus):415805 PLCG2
Monarch:415805 PLCG2
NCBI Gene:415805 PLCG2
Reference Transcript
RefSeq:XM_004944258.2 PLCG2
RefSeq:XM_414166.5 PLCG2
Other Identifiers
415805
GO:0003824
GO:0004435
GO:0005515
GO:0006629
GO:0007165
GO:0008081
GO:0009395
GO:0010634
GO:0016042
GO:0016787
GO:0023052
GO:0035556
GO:0048015
GO:0048870
GO:0050896
GO:0051209
GO:0055065
GO:0055085
GT_A_87_P019490
Gga.7148.1.S1_at
GgaAffx.22378.1.S1_at
GgaAffx.22378.1.S1_s_at
GgaAffx.3425.1.S1_at
Participates
as an input of
p-DAPP1 (p-BAM32) binds PLCG2 (Gallus gallus)
as a component of
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Gallus gallus)
PLCG2:PIP3 [plasma membrane] (Gallus gallus)
as a member of
PLC gamma1,2 [cytosol] (Gallus gallus)
This entity regulates
Positively
Endocytosis of TLR4:LY96:LPS:CD14
(Gallus gallus)
Other forms of this molecule
phospho-PLCG2 [cytosol]
phospho-PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
PLCG2 [plasma membrane]
phospho-PLCG2 [plasma membrane]
Inferred From
PLCG2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_004944315.1
,
XP_414166.4
OpenTargets
ENSG00000197943
Ensembl
ENSGALT00010017628
,
ENSGALG00010007393
,
ENSGALP00010009743
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