Reactome | POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]

POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HCV-8854138

Type

Protein [EntityWithAccessionedSequence]

Species

Hepatitis C virus subtype 1a

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

POLG_HCVH

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27958 POLG

Gene Names

POLG

Chain

initiator methionine:, chain:2-3011, chain:2-191, chain:2-177, propeptide:178-191, chain:192-383, chain:384-746, chain:747-809, chain:810-1026, chain:1027-1657, chain:1658-1711, chain:1712-1972, chain:1973-2420, chain:2421-3011

Participates

as a component of

TBC1D20:POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

as an input of

TBC1D20 binds NS5A (Homo sapiens)

Cross References

OpenTargets

ENSG00000140521

IntEnz

3.4.21.98, 3.6.4.13

PDB

2OC8, 6BZY, 1R7G, 6BZV, 2OC1, 2OBQ, 2QV1, 4CL1, 2JXF, 6BQJ, 2XI2, 5JZI, 4N0Y, 2OIN, 2P59, 1HEI, 5ERW, 6BZU, 1RGQ, 1R7D, 2KDR, 1ONB, 2A4R, 1R7F, 5FGB, 4JZO, 4Q0X, 3RC5, 1A1R, 5YXU, 2O8M, 2OC7, 7DUU, 2OBO, 1N1L, 6WOQ, 6BZW, 2XNI, 2OC0, 4XVJ, 6BQK, 1CWX, 2XI3, 4MWF, 2HD0, 5YXN, 6UYD, 2F9V, 1JR6, 6WO5, 4Z0X, 1R7C, 1A1V, 1R7E, 5FGC, 2N1P, 5EOC, 4JZN, 3RC4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.729	5
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.704	4
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.697	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.656	3
UniProt:P06240 Lck	5	phospho-p-Y394-LCK [plasma membrane] (R-MMU-8857940) Lck [cytosol] (R-MMU-539041) phospho-p-Y505-LCK [plasma membrane] (R-MMU-202159) phospho-p-Y394-LCK [cytosol] (R-MMU-202308) LCK [cytosol] (R-MMU-167609)	0.656	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.463	2

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