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myristoylated nef [cytosol]
Stable Identifier
R-HIV-167605
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
cytosol
GO Cellular Component
host cell cytosol
(0044164)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Uncoating of the HIV Virion (Homo sapiens)
Disintegration of matrix layer (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)
Assembling HIV virion [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Assembling HIV virion [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Myristoylation of Nef (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef and signal transduction (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)
Fyn:Nef Complex [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)
Hck-1:Nef [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)
Lck:Nef [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)
DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef mediated activation of the T-cell receptor (Homo sapiens)
Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef Mediated CD4 Down-regulation (Homo sapiens)
Degradation of CD4 (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD4:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
CD4:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
CD4:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef mediated disruption of CD4:Lck Complex (Homo sapiens)
CD4:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef Mediated CD8 Down-regulation (Homo sapiens)
Degradation of CD8 (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD8:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
CD8:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)
CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane] (Homo sapiens)
CD8:Nef Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef mediated downregulation of CD28 cell surface expression (Homo sapiens)
Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)
Nef:CD28 Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)
CD28:Nef:Clathrin-coated Pit Adapter Protein Complex [plasma membrane] (Homo sapiens)
Nef:CD28 Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef:CD28 Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex (Homo sapiens)
CD28:Nef:Clathrin-coated Pit Adapter Protein Complex [plasma membrane] (Homo sapiens)
Nef:CD28 Complex [plasma membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
Degradation of MHC I Complex (Homo sapiens)
Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of MHC I:Nef Complex (Homo sapiens)
Nef:class I MHC complex [Golgi membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
Nef:class I MHC complex [Golgi membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
myristoylated nef [cytosol] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04601 nef
Gene Names
nef
Chain
initiator methionine:, chain:2-206, chain:58-206
Reference Genes
BioGPS Gene:156110 nef
KEGG:vg:156110 nef
Monarch:156110 nef
NCBI Gene:156110 nef
UCSC:P04601 nef
Reference Transcript
RefSeq:NC_001802.1 nef
Participates
as a component of
Assembling HIV virion [plasma membrane] (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
Nef:class I MHC complex [Golgi membrane] (Homo sapiens)
CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol] (Homo sapiens)
Nef:CD28 Complex [plasma membrane] (Homo sapiens)
Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
CD8:Nef Complex [plasma membrane] (Homo sapiens)
Arf1:Nef:endosomal CD4 [early endosome membrane] (Homo sapiens)
Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] (Homo sapiens)
CD4:Nef Complex [plasma membrane] (Homo sapiens)
Fyn:Nef Complex [cytosol] (Homo sapiens)
Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] (Homo sapiens)
DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)
Lck:Nef [cytosol] (Homo sapiens)
Hck-1:Nef [cytosol] (Homo sapiens)
as an input of
Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)
Formation of MHC I:Nef Complex (Homo sapiens)
Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)
Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
Nef mediated disruption of CD4:Lck Complex (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Fyn (Homo sapiens)
Nef mediated activation of the T-cell receptor (Homo sapiens)
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Lck (Homo sapiens)
Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)
as an output of
Myristoylation of Nef (Homo sapiens)
Disintegration of matrix layer (Homo sapiens)
Degradation of MHC I Complex (Homo sapiens)
Degradation of CD8 (Homo sapiens)
Degradation of CD4 (Homo sapiens)
Other forms of this molecule
nef [cytosol]
myristoylated Nef Protein (UniProt:P04601) [extracellular region]
Modified Residues
Name
N-myristoylglycine at 1
Coordinate
1
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
PDB
8GVB
,
5HGH
,
4NEE
,
3RL2
,
7YG3
,
5HGA
,
4WU5
,
7K81
,
5HGB
,
5HGD
,
4WU7
,
7K80
,
8GVG
,
8GVI
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14734 ACOT8
2
ACOT8 [cytosol]
(R-HSA-9033134)
ACOT8 [peroxisomal matrix]
(R-HSA-193426)
0.706
7
UniProt:Q969X5 ERGI1
0.462
2
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.462
2
UniProt:P30419 NMT1
1
NMT1 [cytosol]
(R-HSA-60306)
0.462
4
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