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VPU (P05919) protein [nucleoplasm]
Stable Identifier
R-HIV-175200
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
GO Cellular Component
host cell nucleoplasm
(0044095)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
1-LTR circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
2-LTR circle formation (Homo sapiens)
Association of Ku heterodimer with viral DNA ends (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
Autointegration results in viral DNA circles (Homo sapiens)
Suicidal integration leading to inverted circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
Integration of viral DNA into host genomic DNA (Homo sapiens)
Target DNA binding (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
VPU (P05919) protein [nucleoplasm] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P05919 vpu
Gene Names
vpu
Chain
chain:1-82
Reference Genes
BioGPS Gene:155945 vpu
KEGG Gene (Hepatitis C Virus):155945 vpu
Monarch:155945 vpu
NCBI Gene:155945 vpu
Reference Transcript
RefSeq:NC_001802.1 vpu
Participates
as a component of
viral PIC proteins [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Other forms of this molecule
VPU (P05919) protein [cytosol]
VPU (P05919) [endoplasmic reticulum membrane]
VPU (P05919) protein [extracellular region]
VPU (P05919) [Golgi membrane]
VPU (P05919) [plasma membrane]
Cross References
RefSeq
NP_057855.1
PDB
2N29
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.597
3
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.597
4
UniProt:P01730 CD4
4
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
CD4 [early endosome]
(R-HSA-182147)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [plasma membrane]
(R-HSA-167542)
0.524
3
UniProt:P13598 ICAM2
1
ICAM2 [plasma membrane]
(R-HSA-197852)
0.462
2
UniProt:Q9NQC3 RTN4
1
RTN4 [plasma membrane]
(R-HSA-194556)
0.462
4
UniProt:Q63HN8 RNF213
3
RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715284)
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715291)
RNF213 [cytosol]
(R-HSA-9635613)
0.462
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.462
2
UniProt:Q9GZT3 SLIRP
1
SLIRP [mitochondrial matrix]
(R-HSA-9837039)
0.462
4
UniProt:Q99653 CHP1
1
p-CHP1 [plasma membrane]
(R-HSA-5333747)
0.462
2
UniProt:P42695 NCAPD3
3
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.462
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.462
4
UniProt:Q8TC07 TBC1D15
1
TBC1D15 [cytosol]
(R-HSA-8854150)
0.462
2
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.462
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.462
4
UniProt:O14828 SCAM3
0.462
4
UniProt:Q9UHQ9 CYB5R1
3
CYB5R1 [plasma membrane]
(R-HSA-8848888)
CYB5R1 [platelet alpha granule membrane]
(R-HSA-8848891)
CYB5R1 [endoplasmic reticulum membrane]
(R-HSA-6806847)
0.462
4
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.462
4
UniProt:P78357 CNTNAP1
1
CNTNAP1 [plasma membrane]
(R-HSA-373626)
0.462
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.462
2
UniProt:Q9NVI7 ATD3A
0.462
4
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.462
2
UniProt:Q9HAV4 XPO5
2
XPO5 [cytosol]
(R-HSA-847719)
XPO5 [nucleoplasm]
(R-HSA-847721)
0.462
2
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.462
2
UniProt:Q96P70 IPO9
0.462
4
UniProt:Q96F15 GIMA5
0.462
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.462
2
UniProt:P48047 ATP5PO
1
ATP5PO [mitochondrial inner membrane]
(R-HSA-164533)
0.462
2
UniProt:Q86XR8 CEP57
1
CEP57 [cytosol]
(R-HSA-380271)
0.462
2
UniProt:P30049 ATP5F1D
1
ATP5F1D [mitochondrial matrix]
(R-HSA-164574)
0.462
2
UniProt:O95573 ACSL3
2
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
0.462
2
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.462
2
UniProt:Q969Z0 TBRG4
1
TBRG4 [mitochondrial matrix]
(R-HSA-9837166)
0.462
2
UniProt:Q9Y6D6 BIG1
0.462
2
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.462
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.462
4
UniProt:P18859 ATP5PF
1
ATP5PF [mitochondrial inner membrane]
(R-HSA-164532)
0.462
4
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.462
4
UniProt:Q5T9A4 ATAD3B
3
ATAD3B [ficolin-1-rich granule membrane]
(R-HSA-6801277)
ATAD3B [plasma membrane]
(R-HSA-6806518)
ATAD3B [secretory granule membrane]
(R-HSA-6801313)
0.462
4
UniProt:P06576 ATP5F1B
6
ATP5F1B [mitochondrial matrix]
(R-HSA-164576)
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
0.462
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.462
4
UniProt:Q86T03 TMEM55B
2
TMEM55B [late endosome membrane]
(R-HSA-6810395)
TMEM55B [nucleoplasm]
(R-HSA-6810405)
0.462
4
UniProt:Q9UBB4 ATX10
0.462
4
UniProt:P20020 ATP2B1
1
ATP2B1 [plasma membrane]
(R-HSA-418301)
0.462
2
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