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MA (P04585) protein [nucleoplasm]
Stable Identifier
R-HIV-3006250
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
1-LTR circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
2-LTR circle formation (Homo sapiens)
Association of Ku heterodimer with viral DNA ends (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Autointegration results in viral DNA circles (Homo sapiens)
Suicidal integration leading to inverted circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
Integration of viral DNA into host genomic DNA (Homo sapiens)
Target DNA binding (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
viral PIC proteins [nucleoplasm] (Homo sapiens)
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
MA (P04585) protein [nucleoplasm] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04585 gag-pol
Gene Names
gag-pol
Chain
initiator methionine:, chain:2-1435, chain:2-132, chain:133-363, peptide:364-377, chain:378-432, peptide:433-440, chain:441-488, chain:489-587, chain:588-1147, chain:588-1027, chain:1028-1147, chain:1148-1435
Reference Genes
BioGPS Gene:155348 gag-pol
KEGG Gene (Hepatitis C Virus):155348 gag-pol
Monarch:155348 gag-pol
NCBI Gene:155348 gag-pol
Reference Transcript
RefSeq:NC_001802.1 gag-pol
Participates
as a member of
Matrix [nucleoplasm] (Human immunodeficiency virus 1)
Other forms of this molecule
GAG-POL Polyprotein (P04585) [extracellular region]
GAG-POL Polyprotein (P04585) [plasma membrane]
IN (Integrase) (P04585) protein [nucleoplasm]
p6 (P04585) [nucleoplasm]
NC (P04585) protein [cytosol]
CA (P04585) protein [cytosol]
PR (Protease) (P04585) protein [cytosol]
p6 (P04585) protein [extracellular region]
p51 (RT) [extracellular region]
Reverse transcriptase/ribonuclease H [extracellular region]
CA (P04585) protein [extracellular region]
PR (Protease) (P04585) protein [extracellular region]
IN (Integrase) (P04585) protein [extracellular region]
MA (P04585) protein [extracellular region]
NC (P04585) protein [extracellular region]
Reverse transcriptase/ribonuclease H [cytosol]
p51 (RT) [cytosol]
IN (Integrase) (P04585) protein [cytosol]
p6 (P04585) protein [cytosol]
MA (P04585) protein [cytosol]
Cross References
RefSeq
NP_057849.4
IntEnz
3.4.23.16
PRO
P04585
PDB
1S1V
,
1LWE
,
1O1W
,
1A30
,
3KT2
,
6SKN
,
3M8P
,
1FB7
,
7XJ4
,
1JKH
,
5HRR
,
1FKP
,
6UIT
,
1C0U
,
6OTZ
,
3C6T
,
1JLA
,
1S1X
,
1ODW
,
6EX9
,
6SLQ
,
3KJV
,
6DJ7
,
1BWA
,
3TAM
,
2YNG
,
6WAZ
,
1LWF
,
6GL1
,
1TKX
,
2YNH
,
6OR7
,
1TAM
,
6UJX
,
2HNY
,
1RT3
,
3I0R
,
1QBU
,
1HIV
,
2NPH
,
3KT5
,
1BV7
,
6BSG
,
3M8Q
,
7XJ5
,
5EU7
,
3LP0
,
5HRS
,
2HND
,
1C1B
,
7XJ7
,
6J1V
,
5T82
,
1JLB
,
1RTD
,
1G6L
,
3C6U
,
3KK1
,
1ESK
,
3N3I
,
1EX4
,
6SLU
,
1ODY
,
1TKZ
,
4KSE
,
2YNI
,
6UJY
,
1BV9
,
2HNZ
,
5K14
,
3I0S
,
4KV8
,
3DLE
,
3AO2
,
1EXQ
,
3LP1
,
6SMU
,
6BSH
,
2WOM
,
1EP4
,
6J1W
,
3DI6
,
1C1C
,
8FCC
,
1JLC
,
1RT7
,
3FFI
,
6WB1
,
4QLH
,
3KK2
,
1RT4
,
6VPZ
,
1TL1
,
2OPP
,
6UJZ
,
3NBP
,
1RTJ
,
3DLG
,
1DTQ
,
3PHV
,
5KAO
,
6BSI
,
2WON
,
3LP2
,
8FCD
,
3DM2
,
3LAK
,
6P1I
,
6BSJ
,
3E01
,
6DIF
,
1JLE
,
6BJ2
,
6DV0
,
3KK3
,
6PYL
,
4Q1W
,
6UK0
,
6VQ2
,
5DGU
,
1TL3
,
2OPQ
,
1DTT
,
1HVH
,
1REV
,
3MEC
,
3MED
,
7R7V
,
1BVG
,
8FCE
,
3LAL
,
1JLF
,
1RTH
,
1VRT
,
6BJ3
,
1BWB
,
3QIN
,
6P1X
,
1C0T
,
6DIL
,
4Q5M
,
6DV4
,
4U1H
,
1FK9
,
3DMJ
,
3DOK
,
6WPF
,
4U7Q
,
1S1W
,
4Q1X
,
5J2M
,
4Q1Y
,
6WPH
,
4U7V
,
6P2G
,
5TC2
,
1LV1
,
5DGW
,
2OPR
,
6E7J
,
5VZ6
,
6VQD
,
1HWR
,
4I7F
,
4B3O
,
1JLQ
,
5XOS
,
1JLG
,
3MEE
,
3LAM
,
1VRU
,
1QBS
,
5IM7
,
3DYA
,
7R7X
,
3QIO
,
6DJ1
,
4U1I
,
1HVR
,
3DOL
,
5J2N
,
6E9A
,
1E6J
,
2WHH
,
5J2P
,
1S1T
,
2OPS
,
6WPJ
,
3DOX
,
1HXB
,
1RT2
,
6SKK
,
6VQE
,
5HRN
,
1LW2
,
5XOT
,
1RT1
,
4B3P
,
3DRP
,
1FKO
,
4B3Q
,
3DRR
,
6UIR
,
1NCP
,
7R80
,
1LW0
,
3MEG
,
2RKI
,
3LAN
,
1BVE
,
1DMP
,
1RT6
,
6VQY
,
7SLR
,
1T05
,
3QIP
,
6DJ2
,
3T19
,
4U1J
,
2KOD
,
5YRS
,
1QBR
,
2YNF
,
5J2Q
,
1S1U
,
3T1A
,
1LWC
,
1TKT
,
1QBT
,
6SKM
,
4NCG
,
1KLM
,
1RTI
,
2RF2
,
7XIU
,
5HRP
,
6UIS
,
6EWA
,
3DRS
,
6VQZ
,
7SLS
,
6DJ5
,
1RT5
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04585 gag-pol
20
GAG-POL Polyprotein (P04585) [extracellular region]
(R-HIV-3139031)
GAG-POL Polyprotein (P04585) [plasma membrane]
(R-HIV-3076336)
MA (P04585) protein [nucleoplasm]
(R-HIV-3006250)
IN (Integrase) (P04585) protein [nucleoplasm]
(R-HIV-175288)
p6 (P04585) [nucleoplasm]
(R-HIV-175300)
NC (P04585) protein [cytosol]
(R-HIV-3006251)
CA (P04585) protein [cytosol]
(R-HIV-3006247)
PR (Protease) (P04585) protein [cytosol]
(R-HIV-175182)
p6 (P04585) protein [extracellular region]
(R-HIV-175560)
p51 (RT) [extracellular region]
(R-HIV-175342)
Reverse transcriptase/ribonuclease H [extracellular region]
(R-HIV-175316)
CA (P04585) protein [extracellular region]
(R-HIV-175492)
PR (Protease) (P04585) protein [extracellular region]
(R-HIV-173391)
IN (Integrase) (P04585) protein [extracellular region]
(R-HIV-175406)
MA (P04585) protein [extracellular region]
(R-HIV-175359)
NC (P04585) protein [extracellular region]
(R-HIV-3006248)
Reverse transcriptase/ribonuclease H [cytosol]
(R-HIV-173370)
p51 (RT) [cytosol]
(R-HIV-173834)
IN (Integrase) (P04585) protein [cytosol]
(R-HIV-173387)
p6 (P04585) protein [cytosol]
(R-HIV-3072746)
0.73
29
UniProt:P03366 POL
0.623
2
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