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myristoylated Nef Protein (UniProt:P04601) [extracellular region]
Stable Identifier
R-HIV-3597665
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
extracellular region
GO Cellular Component
host cell cytosol
(0044164)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Conformational change in gp120 of Env oligomer (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Conformational changes in gp120 exposes gp41 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Fusogenic activation of gp41 (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Maturation of HIV Virion (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
Mature HIV virion [extracellular region] (Homo sapiens)
myristoylated Nef Protein (UniProt:P04601) [extracellular region] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04601 nef
Gene Names
nef
Chain
initiator methionine:, chain:2-206, chain:58-206
Reference Genes
BioGPS Gene:156110 nef
KEGG:vg:156110 nef
Monarch:156110 nef
NCBI Gene:156110 nef
UCSC:P04601 nef
Reference Transcript
RefSeq:NC_001802.1 nef
Participates
as a component of
Immature HIV virion [extracellular region] (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
Other forms of this molecule
nef [cytosol]
myristoylated nef [cytosol]
Modified Residues
Name
N-myristoylglycine at 1
Coordinate
1
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
PDB
8GVB
,
5HGH
,
4NEE
,
3RL2
,
7YG3
,
5HGA
,
4WU5
,
7K81
,
5HGB
,
5HGD
,
4WU7
,
7K80
,
8GVG
,
8GVI
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14734 ACOT8
2
ACOT8 [cytosol]
(R-HSA-9033134)
ACOT8 [peroxisomal matrix]
(R-HSA-193426)
0.706
7
UniProt:Q969X5 ERGI1
0.462
2
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.462
2
UniProt:P30419 NMT1
1
NMT1 [cytosol]
(R-HSA-60306)
0.462
4
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