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DOCK3 [cytosol]
Stable Identifier
R-HSA-1012973
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 3, DOCK3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q14511 CASL
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FYN (Homo sapiens)
NTRK2 activates RAC1 (Homo sapiens)
DOCK3 binds FYN associated with NTRK2 (Homo sapiens)
DOCK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IZD9 DOCK3
Gene Names
DOCK3, KIAA0299, MOCA
Chain
chain:1-2030
Reference Genes
BioGPS Gene:1795 DOCK3
COSMIC (genes):DOCK3 DOCK3
CTD Gene:1795 DOCK3
dbSNP Gene:1795 DOCK3
ENSEMBL:ENSG00000088538 DOCK3
HGNC:2989 DOCK3
KEGG:hsa:1795 DOCK3
Monarch:1795 DOCK3
NCBI Gene:1795 DOCK3
OMIM:603123 DOCK3
UCSC:Q8IZD9 DOCK3
Reference Transcript
RefSeq:NM_004947.4 DOCK3
Other Identifiers
11727550_at
16941114
1795
213482_PM_at
213482_at
2622971
2622972
2622973
2622974
2622977
2622980
2622982
2622983
2622990
2622991
2622993
2622994
2622996
2622998
2623000
2623005
2623006
2623007
2623008
2623009
2623010
2623011
2623012
2623013
2623014
2623019
2623021
2623022
2623024
2623025
2623027
2623028
2623031
2623032
2623033
2623034
2623035
2623036
2623038
2623040
2623041
2623042
2623043
2623044
2623046
2623048
2623049
2623050
2623052
2623053
2623054
2623055
2623057
2623060
2623061
2623062
2623063
2623064
2623067
2623072
2623073
2623074
2623075
2623076
2623077
2623078
2623081
2623140
2623141
2623142
2623143
2623144
2623145
2675571
36844_at
8080028
8080084
A_14_P105886
A_14_P121546
A_24_P153643
A_24_P272845
GE53040
GO:0005085
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007264
GO:0017124
GO:0031267
GO:0048011
GO:0051056
GO:0098772
HMNXSV003014902
HMNXSV003028767
HMNXSV003050128
Hs.7022.0.S1_3p_at
ILMN_1712352
PH_hs_0000711
PH_hs_0030940
TC03000317.hg
TC03000318.hg
Participates
as a candidate of
RAC2 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
as a member of
RAC1 GEFs [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
as an input of
DOCK3 binds FYN associated with NTRK2 (Homo sapiens)
as a component of
BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1:DOCK3 [plasma membrane] (Homo sapiens)
Inferred To
Homologues of DOCK3 [cytosol]
(Dictyostelium discoideum)
docA [cytosol]
(Dictyostelium discoideum)
DOCK3 [cytosol]
(Bos taurus)
DOCK3 [cytosol]
(Canis familiaris)
DOCK3 [cytosol]
(Gallus gallus)
DOCK3 [cytosol]
(Sus scrofa)
Dock3 [cytosol]
(Mus musculus)
Dock3 [cytosol]
(Rattus norvegicus)
docB [cytosol]
(Dictyostelium discoideum)
docD [cytosol]
(Dictyostelium discoideum)
spg [cytosol]
(Drosophila melanogaster)
docC [cytosol]
(Dictyostelium discoideum)
DCK1 [cytosol]
(Saccharomyces cerevisiae)
dock3 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004938.1
ENSEMBL
ENST00000266037
,
ENSP00000266037
OpenTargets
ENSG00000088538
HPA
ENSG00000088538-DOCK3
PRO
Q8IZD9
Pharos - Targets
Q8IZD9
GlyGen
Q8IZD9
Orphanet
DOCK3
HMDB Protein
HMDBP08354
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92556 ELMO1
1
ELMO1 [cytosol]
(R-HSA-200932)
0.643
4
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q96JJ3 ELMO2
1
ELMO2 [cytosol]
(R-HSA-372642)
0.527
2
UniProt:Q14511 CASL
0.524
2
UniProt:Q13017-1 Q130171
0.499
2
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