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IRF4 [cytosol]
Stable Identifier
R-HSA-1015679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interferon regulatory factor 4, IRF4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9H6S0 YTDC2
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
NPM1-ALK- and p-STAT3-dependent IRF4 gene expression (Homo sapiens)
IRF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15306 IRF4
Gene Names
IRF4, MUM1
Chain
chain:1-451
Reference Genes
BioGPS Gene:3662 IRF4
COSMIC (genes):IRF4 IRF4
CTD Gene:3662 IRF4
dbSNP Gene:3662 IRF4
ENSEMBL:ENSG00000137265 IRF4
ENSEMBL_homo_sapiens_GENE:ENSG00000137265.16 IRF4
HGNC:6119 IRF4
KEGG Gene (Homo sapiens):3662 IRF4
Monarch:3662 IRF4
NCBI Gene:3662 IRF4
OMIM:601900 IRF4
UCSC:Q15306 IRF4
Reference Transcript
RefSeq:NM_001195286.1 IRF4
RefSeq:NM_002460.3 IRF4
Other Identifiers
11717508_at
11717509_at
17004167
204562_PM_at
204562_at
216986_PM_s_at
216986_s_at
2891344
2891346
2891347
2891348
2891349
2891350
2891351
2891357
2891359
2891361
2891367
2891370
2891371
2891372
2891373
2891374
2891375
2891376
2891378
3662
37625_at
37627_g_at
8116559
A_14_P102240
A_14_P106682
A_14_P120538
A_23_P156505
A_23_P214360
GE59232
GO:0000785
GO:0000786
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0003713
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0016020
GO:0023052
GO:0030154
GO:0032733
GO:0032736
GO:0032743
GO:0032753
GO:0034122
GO:0042110
GO:0042832
GO:0043011
GO:0043226
GO:0043565
GO:0045622
GO:0045893
GO:0045944
GO:0048856
GO:0072540
GO:0098542
GO:0120162
GO:0140110
GO:1990837
HMNXSV003039723
Hs.82132.1.S1_3p_a_at
ILMN_1754507
PH_hs_0022403
TC06000005.hg
TC06002353.hg
U52682_at
g4505286_3p_at
Participates
as a member of
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
IRF 1-9 [cytosol] (Homo sapiens)
as an output of
NPM1-ALK- and p-STAT3-dependent IRF4 gene expression (Homo sapiens)
Other forms of this molecule
IRF4 [nucleoplasm]
Cross References
RefSeq
NP_001182215.1
,
NP_002451.2
OpenTargets
ENSG00000137265
GeneCards
Q15306
HPA
ENSG00000137265-IRF4
Ensembl
ENSP00000512940
,
ENST00000380956
,
ENSP00000370343
,
ENSG00000137265
,
ENST00000696871
PRO
Q15306
Pharos - Targets
Q15306
Orphanet
24629
PDB
7RH2
,
7OOT
,
2DLL
,
7O56
,
6TD4
,
7OGS
,
7JM4
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z6J9 TSEN54
1
TSEN54 [nucleoplasm]
(R-HSA-5696764)
0.556
3
UniProt:Q8TF65 GIPC2
0.556
5
UniProt:Q86UE8 TLK2
0.499
2
UniProt:Q9H6S0 YTDC2
0.499
2
UniProt:O95163 IKBKAP
1
IKBKAP [nucleoplasm]
(R-HSA-193948)
0.499
2
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.499
2
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