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RNASEL [cytosol]
Stable Identifier
R-HSA-1015684
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
2-5A-dependent ribonuclease, RN5A_HUMAN, 2-5A-dependent RNase, Ribonuclease L, RNase L
Icon
Locations in the PathwayBrowser for interactor UniProt:P08247 SYP
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
OAS antiviral response (Homo sapiens)
ABCE1 binds RNASEL (Homo sapiens)
RNASEL [cytosol] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
RNASEL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05823 RNASEL
Gene Names
RNASEL, RNS4
Chain
chain:1-741
Reference Genes
BioGPS Gene:6041 RNASEL
COSMIC (genes):RNASEL RNASEL
CTD Gene:6041 RNASEL
dbSNP Gene:6041 RNASEL
ENSEMBL:ENSG00000135828 RNASEL
ENSEMBL_homo_sapiens_GENE:ENSG00000135828.11 RNASEL
HGNC:10050 RNASEL
KEGG Gene (Homo sapiens):6041 RNASEL
Monarch:6041 RNASEL
NCBI Gene:6041 RNASEL
OMIM:180435 RNASEL
UCSC:Q05823 RNASEL
Reference Transcript
RefSeq:NM_021133.3 RNASEL
Other Identifiers
11734358_a_at
11734359_a_at
16697004
221287_PM_at
221287_at
229285_PM_at
229285_at
2447128
2447129
2447130
2447131
2447132
2447133
2447134
2447135
2447138
2447139
2447141
2447142
2447143
2447144
2447145
2447146
46123_at
6041
7922707
A_23_P390172
GE82590
GE87744
GO:0000166
GO:0003723
GO:0003824
GO:0004518
GO:0004519
GO:0004521
GO:0004540
GO:0004672
GO:0005515
GO:0005524
GO:0005575
GO:0005634
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006351
GO:0006355
GO:0006364
GO:0006396
GO:0006397
GO:0006468
GO:0016071
GO:0016363
GO:0016740
GO:0016787
GO:0019843
GO:0030154
GO:0036211
GO:0042254
GO:0042802
GO:0043021
GO:0043226
GO:0043488
GO:0045071
GO:0045444
GO:0045944
GO:0046326
GO:0046872
GO:0051607
GO:0055085
GO:0098542
GO:0140096
GO:0140098
HMNXSV003057568
Hs.56156.0.A1_3p_at
ILMN_1671281
ILMN_2210601
L10381_at
PH_hs_0024628
TC01003607.hg
g10863928_3p_at
Participates
as a component of
ABCE1:RNASEL [cytosol] (Homo sapiens)
RNASEL:2'-5' oligoadenylate [cytosol] (Homo sapiens)
RNASEL:FLNA [cytosol] (Homo sapiens)
as an input of
ABCE1 binds RNASEL (Homo sapiens)
as an output of
Expression of IFN-induced genes (Homo sapiens)
Other forms of this molecule
RNASEL [mitochondrial matrix]
Inferred To
asb18 [cytosol]
(Xenopus tropicalis)
Rnasel [cytosol]
(Mus musculus)
Rnasel [cytosol]
(Rattus norvegicus)
RNASEL [cytosol]
(Bos taurus)
RNASEL [cytosol]
(Canis familiaris)
RNASEL [cytosol]
(Gallus gallus)
RNASEL [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_066956.1
OpenTargets
ENSG00000135828
ZINC - Substances
RN5A_HUMAN
ZINC target
Q05823
PRO
Q05823
PDB
4OAV
,
1WDY
,
4G8K
,
4G8L
,
4OAU
GeneCards
Q05823
HPA
ENSG00000135828-RNASEL
Ensembl
ENST00000539397
,
ENST00000367559
,
ENSP00000356530
,
ENSP00000440844
,
ENSG00000135828
Pharos - Targets
Q05823
Orphanet
15217
ZINC - Predictions - Purchasable
RN5A_HUMAN
HMDB Protein
HMDBP08807
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.837
8
UniProt:Q92187 ST8SIA4
1
ST8SIA4 [Golgi membrane]
(R-HSA-422390)
0.527
2
UniProt:P08247 SYP
1
SYP [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-5215991)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:Q99677 LPAR4
1
LPAR4 [plasma membrane]
(R-HSA-418020)
0.527
2
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.499
2
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