Expression of IFN-induced genes

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Reaction [omitted]
Homo sapiens
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Around 300 IFN-induced genes have been identified from different oligonucleotide microarray studies in melanoma (WM9) and fibrosarcoma (HT1080) cell lines as well as from human dendritic cells treated with IFN. Only the proteins which are well studied and their function characterized are represented here.
Literature References
PubMed ID Title Journal Year
9861020 Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

Silverman, RH, Williams, BR, Der, SD, Zhou, A

Proc Natl Acad Sci U S A 1998
14769151 Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2

Ozdemir, A, Sun, Y, Leaman, DW, Borden, EC, Yi, T, Chawla-Sarkar, M, Williams, BR, Jacobs, B, Vyas, K

J Interferon Cytokine Res 2003
6548414 Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

McMahon, M, Stark, GR, Kerr, IM, Friedman, RL, Manly, SP

Cell 1984
1730654 Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts

Tan, YH, Cao, XM, Sukhatme, VP, Guy, GR

J Biol Chem 1992
12029096 Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

Tamai, K, Leaman, DW, Borden, EC, Toji, S, Chawla-Sarkar, M, Reheman, M, Vyas, K

J Biol Chem 2002
11337497 Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells

Kalvakolanu, DV, Bauer, JA, Lindner, DJ, Morrison, BH

J Biol Chem 2001
11092454 Gene structure and function of the 2'-5'-oligoadenylate synthetase family

Hartmann, R, Justesen, J, Kjeldgaard, NO

Cell Mol Life Sci 2000
23121362 Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells

Zhang, X, Lempicki, RA, Young, H, Sheikh, F, Yang, J, Donnelly, RP, Sherman, A, Kohli, A, Russell, RS, Masur, H, Imamichi, T, Kottilil, S

J. Viral Hepat. 2012
30485383 Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

Rastgou Talemi, S, Höfer, T, McLauchlan, J, Garcia, KC, Mendoza, JL, Albrecht, D, Bormann, F, Pervolaraki, K, Stanifer, ML, Boulant, S, Bamford, C

PLoS Pathog. 2018
11404376 Functional classification of interferon-stimulated genes identified using microarrays

de Veer, MJ, Walker, E, Der, S, Silverman, RH, Frevel, M, Williams, BR, Holko, M, Paranjape, JM

J Leukoc Biol 2001
2211721 Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon

Marié, I, Svab, J, Robert, N, Hovanessian, AG, Galabru, J

J Biol Chem 1990
688397 Interferon-associated, dsRNA-dependent enzyme activities in a mutant 3T6 cell engaged in the semiconstitutive synthesis of interferon

Colby, C, Ball, A, Sen, GC, Ratner, L, White, C, Gupta, SL, Jarvis, AP

Cell 1978
6162102 Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease

Wreschner, DH, Kerr, IM, Skehel, JJ, McCauley, JW

Nature 1981
16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Denison, C, Krug, RM, Huibregtse, JM, Gygi, S, Zhao, C

Proc Natl Acad Sci U S A 2005
9096384 A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

Weissmann, C, Yang, YL, Williams, BR, Der, SD

Proc Natl Acad Sci U S A 1997
15047845 Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus

Mousavi-Jazi, M, Magnusson, KE, Bladh, L, Andersson, I, Lundkvist, A, Mirazimi, A, Haller, O

J Virol 2004
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