Reactome | FUT8 [Golgi membrane]

FUT8 [Golgi membrane]

Stable Identifier

R-HSA-1028782

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-1,6-fucosyltransferase 8, FUT8_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike trimer glycoside chains get additional branches (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYC5 FUT8

Gene Names

FUT8

Chain

chain:1-575

Reference Genes

BioGPS Gene:2530 FUT8

COSMIC (genes):FUT8 FUT8

CTD Gene:2530 FUT8

dbSNP Gene:2530 FUT8

ENSEMBL:ENSG00000033170 FUT8

HGNC:4019 FUT8

KEGG:hsa:2530 FUT8

Monarch:2530 FUT8

NCBI Gene:2530 FUT8

OMIM:602589 FUT8

UCSC:Q9BYC5 FUT8

Reference Transcript

Other Identifiers

11741568_a_at

11749723_a_at

1554930_PM_a_at

1554930_a_at

16785483

203988_PM_s_at

203988_s_at

2530

3540496

3540553

3540554

3540555

3540556

3540561

3540563

3540564

3540568

3540572

3540573

3540574

3540575

3540576

3540585

3540586

3540588

3540592

3540595

3540605

3540606

3540614

3540615

3540616

3540618

3540623

3540624

3540625

3540626

3540627

3540628

3540669

41628_at

42282_at

7975136

A_14_P109106

A_14_P113075

A_23_P313632

D89289_at

GE60337

GO:0000139

GO:0001701

GO:0003824

GO:0005515

GO:0005794

GO:0005975

GO:0006486

GO:0006487

GO:0006491

GO:0007179

GO:0007229

GO:0007585

GO:0008424

GO:0009312

GO:0010468

GO:0010761

GO:0016020

GO:0016477

GO:0016740

GO:0016757

GO:0016758

GO:0017124

GO:0018279

GO:0019082

GO:0032580

GO:0036071

GO:0042355

GO:0043112

GO:0046368

GO:0046921

GO:0048856

GO:0048870

GO:0055086

GO:0070062

GO:0140096

GO:1900407

GO:1901135

HMNXSV003010961

Hs2.118722.3.S1_3p_s_at

ILMN_1693152

ILMN_1741422

PH_hs_0006549

TC14000397.hg

TC14001735.hg

g4758407_3p_a_at

p33676

Inferred To

FUT8 [Golgi membrane] (Bos taurus)

FUT8 [Golgi membrane] (Canis familiaris)

FUT8 [Golgi membrane] (Dictyostelium discoideum)

FUT8 [Golgi membrane] (Gallus gallus)

FUT8 [Golgi membrane] (Sus scrofa)

FucT6 [Golgi membrane] (Drosophila melanogaster)

Fut8 [Golgi membrane] (Mus musculus)

Fut8 [Golgi membrane] (Rattus norvegicus)

fut-8 [Golgi membrane] (Caenorhabditis elegans)

fut8 [Golgi membrane] (Xenopus tropicalis)

fut8a [Golgi membrane] (Danio rerio)

Cross References

RefSeq

NP_004471.4, NP_835369.1, NP_835368.1, XP_047287137.1, NP_001358463.1, XP_054231711.1, NP_001358462.1

OpenTargets

ENSG00000033170

ENSEMBL

ENST00000342677, ENSP00000353910, ENSP00000345865, ENSP00000378087, ENSP00000452433, ENSG00000033170, ENST00000394586, ENST00000557164, ENST00000360689, ENSP00000501213, ENST00000673929

HPA

ENSG00000033170-FUT8

GeneCards

FUT8

PRO

Q9BYC5

Pharos - Targets

Q9BYC5

GlyGen

Q9BYC5

HMDB Protein

HMDBP05922

PDB

6X5H, 6X5R, 6X5T, 6X5S, 2DE0, 6X5U, 6VLD, 6VLE

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.643	3
UniProt:O14863 ZNT4			0.643	3
UniProt:O14764 GBRD			0.643	4
UniProt:Q92581 SLC9A6	6	SLC9A6 [early endosome membrane] (R-HSA-425984) SLC9A6 H171fs60 [early endosome membrane] (R-HSA-5661079) SLC9A6 338-340del [early endosome membrane] (R-HSA-5661042) SLC9A6 R468 [early endosome membrane] (R-HSA-5661072) SLC9A6 E547* [early endosome membrane] (R-HSA-5661037) SLC9A6 E255_S256del [early endosome membrane] (R-HSA-5661066)	0.643	5
UniProt:Q96DT7-3 ZBTB10			0.556	3
UniProt:P26572 MGAT1	1	MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-964750)	0.527	3
UniProt:O75752 B3GALNT1	1	B3GALNT1 [Golgi membrane] (R-HSA-8878918)	0.527	2
UniProt:Q16706 MAN2A1	2	MAN2A1 [transport vesicle] (R-HSA-8847487) MAN2A1 [Golgi membrane] (R-HSA-975823)	0.527	3
UniProt:Q14314 FGL2	2	FGL2 [extracellular region] (R-HSA-6801586) FGL2 [ficolin-1-rich granule lumen] (R-HSA-6801499)	0.527	2
UniProt:P08842 STS	3	STS [endoplasmic reticulum lumen] (R-HSA-1614318) OxA-STS [endoplasmic reticulum lumen] (R-HSA-1614333) OxA-STS [endoplasmic reticulum membrane] (R-HSA-1606833)	0.527	2
UniProt:Q96AQ6 PBIP1			0.527	4
UniProt:Q9BX97 PLVAP			0.527	2
UniProt:Q6P5W5 SLC39A4	9	SLC39A4 [plasma membrane] (R-HSA-442399) SLC39A4 1223_1227del [plasma membrane] (R-HSA-5654119) SLC39A4 L549del [plasma membrane] (R-HSA-5654135) SLC39A4 G330D [plasma membrane] (R-HSA-5654117) SLC39A4 P200L [plasma membrane] (R-HSA-5654131) SLC39A4 Q323Qfs*25 [plasma membrane] (R-HSA-5654109) SLC39A4 G512W [plasma membrane] (R-HSA-5654106) SLC39A4 G526R [plasma membrane] (R-HSA-5654120) SLC39A4 R95C [plasma membrane] (R-HSA-5654137)	0.527	3
UniProt:O60503 ADCY9	1	ADCY9 [plasma membrane] (R-HSA-379055)	0.527	3
UniProt:Q3MIR4 CC50B			0.527	2
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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