Reactome | PML [nucleoplasm]

PML [nucleoplasm]

Stable Identifier

R-HSA-1031706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable transcription factor PML, PML_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P03255-1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        PML [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - Regulation of RUNX1 Expression and Activity (Homo sapiens)
        
        PML binds RUNX1 (Homo sapiens)
        
        PML [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29590 PML

Gene Names

PML, MYL, PP8675, RNF71, TRIM19

Chain

chain:1-882

Reference Genes

BioGPS Gene:5371 PML

COSMIC (genes):PML PML

CTD Gene:5371 PML

dbSNP Gene:5371 PML

ENSEMBL:ENSG00000140464 PML

HGNC:9113 PML

KEGG:hsa:5371 PML

Monarch:5371 PML

NCBI Gene:5371 PML

OMIM:102578 PML

UCSC:P29590 PML

Reference Transcript

Participates

as a member of

PML,TRIM27,PIAS1,2-1 [nucleoplasm] (Homo sapiens)

as an input of

as a component of

as an output of

Expression of IFNG-stimulated genes (Homo sapiens)

This entity regulates

Negatively

USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)

Other forms of this molecule

PML [cytosol]

monoSUMO1-K65,160,490-PML [nucleoplasm]

polySUMO2-K65,K160,K490-PML [nucleoplasm]

polySUMO3-K65,K160,K490-PML [nucleoplasm]

Inferred To

tam-1 [nucleoplasm] (Caenorhabditis elegans)

nhl-2 [nucleoplasm] (Caenorhabditis elegans)

trim13 [nucleoplasm] (Danio rerio)

Pml [nucleoplasm] (Mus musculus)

Pml [nucleoplasm] (Rattus norvegicus)

nhl-3 [nucleoplasm] (Caenorhabditis elegans)

mei-P26 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PML [nucleoplasm] (Xenopus tropicalis)

Homologues of PML [nucleoplasm] (Caenorhabditis elegans)

PML [nucleoplasm] (Bos taurus)

PML [nucleoplasm] (Canis familiaris)

PML [nucleoplasm] (Dictyostelium discoideum)

PML [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_150243.2, NP_150252.1, NP_150249.1, NP_150241.2, NP_002666.1, NP_150242.1, NP_150250.2, NP_150253.2, NP_150247.2

OpenTargets

ENSG00000140464

ENSEMBL

ENSG00000140464, ENSP00000268058, ENST00000436891, ENSP00000455838, ENST00000395132, ENSP00000268059, ENST00000565898, ENST00000395135, ENST00000564428, ENSP00000456486, ENST00000359928, ENSP00000315434, ENST00000569477, ENSP00000395576, ENSP00000394642, ENSP00000457023, ENST00000567543, ENST00000435786, ENST00000354026, ENSP00000456277, ENST00000569965, ENST00000268059, ENSP00000378567, ENSP00000455612, ENST00000268058, ENSP00000353004, ENSP00000378564

GeneCards

PML

HPA

ENSG00000140464-PML

PRO

P29590

Pharos - Targets

P29590

GlyGen

P29590

Orphanet

PML

HMDB Protein

HMDBP14480

PDB

8DJI, 6UYU, 8DJH, 6UYR, 6UYS, 4WJN, 1BOR, 8J2P, 4WJO, 2MVW, 6UYQ, 6UYP, 8J25, 6IMQ, 2MWX, 6UYV, 6UYO, 5YUF, 6UYT

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.832	6
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.813	11
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.791	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.7	4
UniProt:P03243-1			0.621	3
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.611	7
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.609	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557)	0.589	3
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.571	6
UniProt:Q8UN00 Q8UN00			0.556	4
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.553	2
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.527	2
UniProt:P02585 TNNC2	1	TNNC2 [cytosol] (R-HSA-390531)	0.527	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.527	2
UniProt:Q9HD26 GOPC	3	GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067) GOPC [plasma membrane] (R-HSA-5626572) GOPC [lysosomal membrane] (R-HSA-5627281)	0.527	2
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.527	2
UniProt:Q9Y5W9 SNX11			0.527	2
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.527	2
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.524	4
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.508	2
UniProt:O15055 PER2	5	PER2 [cytosol] (R-HSA-400399) p-7S-PER2 [nucleoplasm] (R-HSA-9920680) p-7S-PER2 [cytosol] (R-HSA-9920710) p-S396-PER2 [cytosol] (R-HSA-9920705) K48polyUb-K,p-7S-PER2 [cytosol] (R-HSA-9932526)	0.463	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.463	2
UniProt:P27958-PRO_0000037566			0.463	6
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.463	2
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.463	3
UniProt:P03255-1			0.463	2

Cite Us!