NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP

Stable Identifier
Reaction [transition]
Homo sapiens
AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E]
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5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular AMP, dAMP, GMP, or IMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Literature References
PubMed ID Title Journal Year
1637327 5'-nucleotidase: molecular structure and functional aspects

Zimmermann, H

Biochem J 1992
2129526 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form

Ogata, S, Ikehara, Y, Misumi, Y, Hirose, S, Ohkubo, K

Eur J Biochem 1990
3036115 Purification of 5'-nucleotidase from human placenta after release from plasma membranes by phosphatidylinositol-specific phospholipase C

Low, MG, Thompson, LF, Ruedi, JM

Biochem Biophys Res Commun 1987
Catalyst Activity

5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]

Orthologous Events
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