CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

5'-nucleotidase (NT5E) associated with the plasma membrane catalyzes the reactions of extracellular CMP, TMP, or UMP with H2O to yield the corresponding nucleoside and orthophosphate. The active enzyme is a glycolipid-anchored dimer (Misumi et al. 1990; Thompson et al. 1987; Zimmerman 1992)

Literature References
PubMed ID Title Journal Year
2826576 Distribution of ecto-5'-nucleotidase on subsets of human T and B lymphocytes as detected by indirect immunofluorescence using goat antibodies

Thompson, LF, Ruedi, JM, Clement, LT, Low, MG

J. Immunol. 1987
2129526 Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form

Ogata, S, Ikehara, Y, Misumi, Y, Hirose, S, Ohkubo, K

Eur J Biochem 1990
16377327 The importance of having a mentor, and how to find one

Stone, CD

Gastrointest. Endosc. 2006
Catalyst Activity

5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]

Orthologous Events
Cite Us!