Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.
Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.
Hernandez, N
Orphanides, G, Reinberg, D, Lagrange, T
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