Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.
Gaffney, PR, Painter, GF, McCormick, F, Hawkins, PT, Holmes, AB, Reese, CB, Copeland, T, Stokoe, D, Stephens, LR
Lisinski, I, Klein, HW, Gompert, M, Stuhlmann, D, Schmolz, K, Baer, K, Al-Hasani, H
Gaffney, PR, Cohen, P, Reese, CB, Holmes, AB, Alessi, DR, Downes, CP, James, SR
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
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