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PKB-mediated events
Stable Identifier
R-HSA-109703
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PKB-mediated events (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PKB-mediated events (Homo sapiens)
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PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
Participants
Events
PDE3B signalling
(Homo sapiens)
Participates
as an event of
PI3K Cascade (Homo sapiens)
Orthologous Events
PKB-mediated events (Bos taurus)
PKB-mediated events (Caenorhabditis elegans)
PKB-mediated events (Canis familiaris)
PKB-mediated events (Dictyostelium discoideum)
PKB-mediated events (Gallus gallus)
PKB-mediated events (Mus musculus)
PKB-mediated events (Plasmodium falciparum)
PKB-mediated events (Rattus norvegicus)
PKB-mediated events (Sus scrofa)
PKB-mediated events (Xenopus tropicalis)
Authored
Scott, J (2005-05-09)
Tatoud, R (2005-05-09)
Created
de Bono, B (2004-01-20)
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