Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p21 RAS:GDP [plasma membrane]
Stable Identifier
R-HSA-109796
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Constitutive Signaling by Overexpressed ERBB2 (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR3 in disease (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR4 in disease (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA extracellular domain mutants (Homo sapiens)
SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of RAS in B cells (Homo sapiens)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
CD209 activate GTPase RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Intrinsic nucleotide exchange on RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS processing (Homo sapiens)
mature p21 RAS binds GDP (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Regulation of RAS by GAPs (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates RAS (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
EGFR Transactivation by Gastrin (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
RASA1 stimulates RAS GTPase activity (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GRB2 events in EGFR signaling (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC1 events in EGFR signaling (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
GRB2 events in ERBB2 signaling (Homo sapiens)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC1 events in ERBB2 signaling (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
SHC1 events in ERBB4 signaling (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR1 (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
FRS-mediated FGFR2 signaling (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR2 (Homo sapiens)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
FRS-mediated FGFR3 signaling (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR3 (Homo sapiens)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR4 (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by MET (Homo sapiens)
MET activates RAS signaling (Homo sapiens)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
NTRK2 activates RAS signaling through FRS2 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Activated NTRK2 signals through RAS (Homo sapiens)
NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by NTRK3 (TRKC) (Homo sapiens)
Activated NTRK3 signals through RAS (Homo sapiens)
NTRK3 activates RAS through SHC1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Activation of RAS by p-KIT bound SOS1 (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
SHC-related events triggered by IGF1R (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
p21 RAS:GDP [plasma membrane] (Homo sapiens)
Participants
components
GDP [cytosol]
mature p21 RAS [plasma membrane]
(Homo sapiens)
Participates
as a component of
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
as an input of
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers (Homo sapiens)
SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)
RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)
FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)
p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)
Activation of RAS by p-KIT bound SOS1 (Homo sapiens)
GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
CD209 activate GTPase RAS (Homo sapiens)
NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
NTRK2 activates RAS signaling through FRS2 (Homo sapiens)
NTRK3 activates RAS through SHC1 (Homo sapiens)
NMDA-activated RASGRF1 activates RAS (Homo sapiens)
SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
Intrinsic nucleotide exchange on RAS (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers (Homo sapiens)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)
GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
as an output of
mature p21 RAS binds GDP (Homo sapiens)
RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)
RAS GAPs stimulate RAS GTPase activity (Homo sapiens)
RASA1 stimulates RAS GTPase activity (Homo sapiens)
Inferred To
p21 RAS:GDP [plasma membrane]
(Bos taurus)
p21 RAS:GDP [plasma membrane]
(Caenorhabditis elegans)
p21 RAS:GDP [plasma membrane]
(Canis familiaris)
p21 RAS:GDP [plasma membrane]
(Danio rerio)
p21 RAS:GDP [plasma membrane]
(Drosophila melanogaster)
p21 RAS:GDP [plasma membrane]
(Gallus gallus)
p21 RAS:GDP [plasma membrane]
(Mus musculus)
p21 RAS:GDP [plasma membrane]
(Rattus norvegicus)
p21 RAS:GDP [plasma membrane]
(Sus scrofa)
p21 RAS:GDP [plasma membrane]
(Xenopus tropicalis)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
