MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1

Stable Identifier
R-HSA-109822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'GRB2:SOS:SHC-P' are present. At the end of this reaction, 1 molecule of 'GRB2:SHC-P', 1 molecule of 'phospho-SOS', and 1 molecule of 'ADP' are present.

Literature References
PubMed ID Title Journal Year
7739560 Insulin-stimulated disassociation of the SOS-Grb2 complex.

Pessin, JE, Yamauchi, K, Waters, SB

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of MAPK3,(MAPK1) [cytosol]

Physical Entity
MAPK3,(MAPK1) [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Bos taurus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)
Created
Charalambous, M  (2004-04-29)
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