MAP2K1 phosphorylates MAPK3

Stable Identifier
R-HSA-109860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAP2K1 phosphorylates MAPK3
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MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Literature References
PubMed ID Title Journal Year
22177953 MEK1/2 dual-specificity protein kinases: structure and regulation

Roskoski, R Jr

Biochem. Biophys. Res. Commun. 2012
23954936 Mitogen-activated protein kinases in innate immunity

Ley, SC, Arthur, JS

Nat. Rev. Immunol. 2013
8388392 Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

Zheng, CF, Guan, KL

J Biol Chem 1993
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol]

Physical Entity
p-2S-MAP2K1:MAPK3 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Negatively by
Regulator
p-2T-MAP2K1 [cytosol] (Homo sapiens)
Orthologous Events
MAP2K1 phosphorylates MAPK3 (Bos taurus)
MAP2K1 phosphorylates MAPK3 (Danio rerio)
MAP2K1 phosphorylates MAPK3 (Dictyostelium discoideum)
MAP2K1 phosphorylates MAPK3 (Mus musculus)
MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)
MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)
MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)
Authored
Charalambous, M  (2005-02-04)
Reviewed
Greene, LA  (2007-11-08)
Created
Charalambous, M  (2004-04-29)
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