Reactome | MAP2K1 phosphorylates MAPK3

MAP2K1 phosphorylates MAPK3

Stable Identifier

R-HSA-109860

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Literature References

PubMed ID	Title	Journal	Year
22177953	MEK1/2 dual-specificity protein kinases: structure and regulation Roskoski, R Jr	Biochem. Biophys. Res. Commun.	2012
23954936	Mitogen-activated protein kinases in innate immunity Ley, SC, Arthur, JS	Nat. Rev. Immunol.	2013
8388392	Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Zheng, CF, Guan, KL	J Biol Chem	1993