Reactome | cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Stable Identifier

R-HSA-109903

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
195585	Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma Webb, TE, Greenberg, N, Schumm, DE	Biochem J	1977
14609716	Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases Van Rompay, AR, Karlsson, A, Johansson, M	Pharmacol Ther	2003
15130468	Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase Matsuda, A, Suzuki, NN, Inagaki, F, Koizumi, K, Fukushima, M	Structure	2004
11306702	Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M	Mol Pharmacol	2001