cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the reactions of cytidine or uridine with ATP to form CMP or UMP and ADP (Greenberg et al. 1977; Van Rompay et al. 2001). Crystallographic data show the enzyme to be a tetramer (Suzuki et al. 2004). When it is expressed as a fusion construct with green fluorescent protein, the protein localizes primarily to the cytosol of transfected CHO cells (Van Rompay et al. 2003).
Literature References
PubMed ID Title Journal Year
195585 Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

Webb, TE, Greenberg, N, Schumm, DE

Biochem J 1977
14609716 Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases

Van Rompay, AR, Karlsson, A, Johansson, M

Pharmacol Ther 2003
15130468 Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase

Matsuda, A, Suzuki, NN, Inagaki, F, Koizumi, K, Fukushima, M

Structure 2004
11306702 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases

Linden, K, Van Rompay, AR, Norda, A, Karlsson, A, Johansson, M

Mol Pharmacol 2001
Catalyst Activity

nucleoside kinase activity of UCK2 tetramer [cytosol]

Orthologous Events
Cross References
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