Reactome | Elongation by POLH

Elongation by POLH

Stable Identifier

R-HSA-110319

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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After incorporating two dAMPs opposite the thymine-thymine cyclobutane pyrimidine dimer (TT-CPD), DNA polymerase eta (POLH) can continue translesion DNA synthesis (TLS). POLH preferentially incorporates dAMPs and dGMPs, and may introduce one error per every 18-380 nucleotides (dNMPs) added. POLH stalls after incorporation of a mispaired dNMP, which limits POLH- mediated mutagenesis, in addition to the subsequent polymerase switch (Matsuda et al. 2000, Masutani et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10856253	Mechanisms of accurate translesion synthesis by human DNA polymerase eta. Kusumoto, R, Iwai, S, Masutani, C, Hanaoka, F	EMBO J	2000
10801132	Low fidelity DNA synthesis by human DNA polymerase-eta Kunkel, TA, Masutani, C, Matsuda, T, Bebenek, K, Hanaoka, F	Nature	2000