Reactome | Displacement of UNG glycosylase by APEX1 at the AP site

Displacement of UNG glycosylase by APEX1 at the AP site

Stable Identifier

R-HSA-110349

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Displacement of UNG glycosylase by APEX1 at the AP site

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APEX1 (APE1, HAP1), a DNA apurinic/apyrimidinic (AP) site lyase, displaces UNG from the AP site generated by UNG DNA glycosylase activity (Nicholl et al. 1997, Parikh et al. 1998, Akbari et al. 2004, Kuznetsova et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25086253	Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1 Saparbaev, MK, Kuznetsova, AA, Fedorova, OS, Kuznetsov, NA, Ishchenko, AA	Biochim. Biophys. Acta	2014
9724657	Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA Tainer, JA, Bharati, S, Krokan, HE, Mol, CD, Slupphaug, G, Parikh, SS	EMBO J	1998
15479784	Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells Otterlei, M, Peña-Diaz, J, Imai, K, Kavli, B, Hagen, L, Liabakk, NB, Akbari, M, Slupphaug, G, Aas, PA, Durandy, A, Krokan, HE	Nucleic Acids Res.	2004
9200707	Reconstitution of human base excision repair with purified proteins Nicholl, ID, Nealon, K, Kenny, MK	Biochemistry	1997