Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break

Stable Identifier
R-HSA-110375
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After incision of the DNA strand 5' to the apurinic/apyrimidinic (AP) site by APEX1 (APE1), POLB (DNA polymerase beta) excises the 5'-terminal abasic deoxyribose phosphate (5'-dRP), thus removing the AP site (Bennet et al. 1997).
Literature References
PubMed ID Title Journal Year
9207062 Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.

Wilson, DM, Wong, D, Bennett, RA, Demple, B

Proc Natl Acad Sci U S A 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]

Physical Entity
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)
Orthologous Events
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Canis familiaris)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
Cite Us!