Phosphorylation of cPLA2 by ERK-2

Stable Identifier
R-HSA-111898
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ERK2 phosphorylates cPLA2, increasing enzymatic activity. The site of cPLA2 phosphorylation by ERK2 is Ser-505, the major site of cPLA2 phosphorylation observed in phorbol ester-treated cells.

Literature References
PubMed ID Title Journal Year
8381049 cPLA2 is phosphorylated and activated by MAP kinase

Lin, LL, Wartmann, M, Lin, AY, Knopf, JL, Seth, A, Davis, RJ

Cell 1993
Participants
Participates
Catalyst Activity

MAP kinase activity of p-T185,Y187-MAPK1 [cytosol]

Orthologous Events
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