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PRKACB [nucleoplasm]
Stable Identifier
R-HSA-111937
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
cAMP-dependent protein kinase, beta-catalytic subunit , PKA C-beta
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
PKA phosphorylates CREB1 (Homo sapiens)
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
PKA phosphorylates CREB1 (Homo sapiens)
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)
RPS6KA5(MSK1/SAPK1):PKA catalytic subunits [nucleoplasm] (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
PKA phosphorylates CREB1 (Homo sapiens)
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
PKA phosphorylates CREB1 (Homo sapiens)
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
PKA phosphorylates MAPKAPK5 (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
PKA-mediated phosphorylation of CREB (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
PKA phosphorylates CREB1 (Homo sapiens)
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
PKA catalytic subunit translocates to the nucleus (Homo sapiens)
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
PRKACB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22694 PRKACB
Gene Names
PRKACB
Chain
initiator methionine:1, chain:2-351
Reference Genes
BioGPS Gene:5567 PRKACB
COSMIC (genes):PRKACB PRKACB
CTD Gene:5567 PRKACB
dbSNP Gene:5567 PRKACB
ENSEMBL:ENSG00000142875 PRKACB
ENSEMBL:ENSG00000142875.20 PRKACB
HGNC:9381 PRKACB
KEGG Gene (Homo sapiens):5567 PRKACB
Monarch:5567 PRKACB
NCBI Gene:5567 PRKACB
OMIM:176892 PRKACB
UCSC:P22694 PRKACB
Reference Transcript
RefSeq:XM_005271019.1 PRKACB
RefSeq:XM_006710758.1 PRKACB
RefSeq:NM_207578.2 PRKACB
RefSeq:NM_001242862.2 PRKACB
RefSeq:NM_182948.3 PRKACB
RefSeq:NM_001242860.2 PRKACB
RefSeq:NM_001242861.2 PRKACB
RefSeq:NM_001300917.1 PRKACB
RefSeq:NM_002731.3 PRKACB
RefSeq:NM_001242859.2 PRKACB
RefSeq:NM_001300916.1 PRKACB
RefSeq:NM_001242858.2 PRKACB
RefSeq:NM_001242857.2 PRKACB
RefSeq:NM_001300915.1 PRKACB
Other Identifiers
11716703_a_at
11735694_a_at
11754927_x_at
11755434_a_at
16666616
202741_PM_at
202741_at
202742_PM_s_at
202742_s_at
2344397
2344398
2344419
2344420
2344421
2344424
2344430
2344431
2344432
2344433
2344435
2344436
2344437
2344438
2344439
2344440
2344441
2344444
2344445
2344446
2344447
2344449
235780_PM_at
235780_at
36215_at
46322_at
5567
7902594
84201_r_at
A_14_P104414
A_14_P110390
A_14_P134402
A_23_P371410
A_24_P62708
A_33_P3215317
A_33_P3772996
GE57940
GO:0000166
GO:0000287
GO:0001843
GO:0003014
GO:0003091
GO:0003824
GO:0004672
GO:0004674
GO:0004679
GO:0004691
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005952
GO:0006468
GO:0007165
GO:0007188
GO:0010737
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0031625
GO:0034380
GO:0036211
GO:0043226
GO:0048856
GO:0051604
GO:0065003
GO:0070062
GO:0070613
GO:0097546
GO:0106310
GO:0140096
GO:1901621
HMNXSV003001255
HMNXSV003034107
Hs.165446.0.A1_3p_at
Hs.87773.0.S2_3p_at
ILMN_1690314
ILMN_1759922
ILMN_1771523
ILMN_2278112
ILMN_2374234
M34181_at
PH_hs_0040487
TC01004503.hg
g4506056_3p_a_at
Participates
as a member of
Protein Kinase A, catalytic subunits [nucleoplasm] (Homo sapiens)
as a candidate of
PRKACA,(PRKACB,PRKACG,PRKX) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PRKACB [ciliary base]
PRKACB [cytosol]
Inferred To
Homologues of PRKACB [nucleoplasm]
(Danio rerio)
Homologues of PRKACB [nucleoplasm]
(Drosophila melanogaster)
Homologues of PRKACB [nucleoplasm]
(Plasmodium falciparum)
PRKACB [nucleoplasm]
(Danio rerio)
PRKACB [nucleoplasm]
(Drosophila melanogaster)
PRKACB [nucleoplasm]
(Gallus gallus)
PRKACB [nucleoplasm]
(Mus musculus)
PRKACB [nucleoplasm]
(Plasmodium falciparum)
PRKACB [nucleoplasm]
(Rattus norvegicus)
PRKACB [nucleoplasm]
(Xenopus tropicalis)
PRKACA [nucleoplasm]
(Drosophila melanogaster)
PRKACA [nucleoplasm]
(Plasmodium falciparum)
Dmel\CG12069 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001229788.1
,
NP_001229789.1
,
XP_005271076.1
,
NP_001229791.1
,
NP_001287846.1
,
NP_002722.1
,
NP_001229790.1
,
NP_001229787.1
,
NP_997461.1
,
NP_001229786.1
,
NP_001287844.1
,
NP_891993.1
,
XP_006710821.1
,
NP_001287845.1
ZINC - World Drugs
KAPCB_HUMAN
Guide to Pharmacology - Targets
1477
OpenTargets
ENSG00000142875
ZINC - FDA approved
KAPCB_HUMAN
ZINC - Substances
KAPCB_HUMAN
ZINC target
P22694
ZINC - Biogenic
KAPCB_HUMAN
PRO
P22694
ZINC - Investigational
KAPCB_HUMAN
IntEnz
2.7.11.11
HPA
ENSG00000142875-PRKACB
GeneCards
P22694
Ensembl
ENST00000446538
,
ENSP00000481980
,
ENSG00000142875
,
ENST00000610703
,
ENSP00000359719
,
ENSP00000401252
,
ENSP00000378315
,
ENST00000614872
,
ENSP00000479722
,
ENSP00000359723
,
ENSP00000359722
,
ENST00000370685
,
ENST00000394839
,
ENST00000370689
,
ENST00000370688
Pharos - Targets
P22694
ZINC - Predictions - Purchasable
KAPCB_HUMAN
HMDB Protein
HMDBP01415
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.643
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P13861 PRKAR2A
2
PRKAR2A [cytosol]
(R-HSA-57840)
PRKAR2A [ciliary base]
(R-HSA-5610412)
0.527
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
2
UniProt:P17612 PRKACA
3
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.527
4
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