Reactome | FLOT1 [plasma membrane]

FLOT1 [plasma membrane]

Stable Identifier

R-HSA-112174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Flotillin, Flotillin-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75955 FLOT1

Gene Names

FLOT1

Chain

chain:1-427

Reference Genes

COSMIC (genes):FLOT1 FLOT1

ENSEMBL:ENSG00000137312 FLOT1

HGNC:3757 FLOT1

UCSC:O75955 FLOT1

Other Identifiers

10211

11743045_a_at

11743046_a_at

11743047_x_at

11748081_a_at

11748082_x_at

11757316_a_at

17016995

17026737

17028888

17031666

17034121

17034129

17036388

17039163

17041731

208748_PM_s_at

208748_s_at

208749_PM_x_at

208749_x_at

210142_PM_x_at

210142_x_at

2948595

2948596

2948597

2948598

2948599

2948600

2948601

2948602

2948603

2948604

2948605

2948606

2948607

2948610

2948611

2948612

2948613

2948614

2948615

2948616

2948617

2948618

2948619

2948620

2948621

2948622

2948623

2948624

2948625

2948626

2948627

2948628

2948629

40635_at

8124828

8178419

8179688

A_23_P214603

A_23_P314526

A_24_P794833

GE61098

GO:0001819

GO:0001931

GO:0001934

GO:0002020

GO:0002090

GO:0005515

GO:0005765

GO:0005768

GO:0005769

GO:0005815

GO:0005856

GO:0005886

GO:0005901

GO:0005911

GO:0005912

GO:0005925

GO:0007409

GO:0008180

GO:0009897

GO:0016020

GO:0016323

GO:0016600

GO:0022617

GO:0030027

GO:0030198

GO:0030864

GO:0031410

GO:0032092

GO:0032226

GO:0032728

GO:0033227

GO:0034116

GO:0034141

GO:0034451

GO:0034976

GO:0035023

GO:0035255

GO:0042383

GO:0042470

GO:0043123

GO:0043226

GO:0044291

GO:0044853

GO:0044854

GO:0044857

GO:0045121

GO:0045202

GO:0045807

GO:0048643

GO:0048786

GO:0050821

GO:0051580

GO:0061024

GO:0070062

GO:0070528

GO:0071360

GO:0072659

GO:0098691

GO:0098793

GO:0098978

GO:0098982

GO:1901741

GO:1901890

GO:2000049

HMNXSV003004658

Hs.179986.0.A1_3p_a_at

ILMN_1661439

PH_hs_0010655

TC06001508.hg

TC6_apd_hap1000078.hg

TC6_cox_hap2000142.hg

TC6_dbb_hap3000131.hg

TC6_mann_hap4000120.hg

TC6_mcf_hap5000121.hg

TC6_qbl_hap6000132.hg

TC6_ssto_hap7000122.hg

g5114048_3p_a_at

Participates

as a candidate of

as a component of

FLOT1:FLOT2 [plasma membrane] (Homo sapiens)

Inferred To

FLOT1 [plasma membrane] (Bos taurus)

FLOT1 [plasma membrane] (Canis familiaris)

FLOT1 [plasma membrane] (Gallus gallus)

FLOT1 [plasma membrane] (Sus scrofa)

Flot1 [plasma membrane] (Mus musculus)

Flot1 [plasma membrane] (Rattus norvegicus)

flot1 [plasma membrane] (Xenopus tropicalis)

flot1a [plasma membrane] (Danio rerio)

Flo1 [plasma membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000444632, ENSP00000372873, ENST00000383562, ENSP00000391438, ENSP00000365569, ENST00000383382, ENST00000436822, ENSP00000388861, ENST00000376389, ENSP00000373056

OpenTargets

ENSG00000137312

HPA

ENSG00000137312-FLOT1

PRO

O75955

Pharos - Targets

O75955

GlyGen

O75955

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.581	5
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12