Reactome | SH2B2 [cytosol]

Stable Identifier

R-HSA-112195

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH2B adapter protein 2, APS, SH2 and PH domain-containing adapter protein APS

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14492 SH2B2

Gene Names

SH2B2, APS

Chain

chain:1-632

Reference Genes

COSMIC (genes):SH2B2 O144922

dbSNP Gene:10603 O144922

ENSEMBL:ENSG00000160999 SH2B2

Participates

as a member of

as a component of

Other forms of this molecule

p-Y629-SH2B2 [cytosol]

Inferred To

SH2B2 [cytosol] (Bos taurus)

SH2B2 [cytosol] (Canis familiaris)

SH2B2 [cytosol] (Sus scrofa)

Sh2b2 [cytosol] (Mus musculus)

Sh2b2 [cytosol] (Rattus norvegicus)

sh2b2 [cytosol] (Xenopus tropicalis)

Lnk [cytosol] (Drosophila melanogaster)

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.656	7

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