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CBL [cytosol]
Stable Identifier
R-HSA-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CBL E3 ubiquitin protein ligase , Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9C004 SPY4
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Homo sapiens)
PTK6 phosphorylates CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
Binding of CBL to EGFR (Homo sapiens)
CBL [cytosol] (Homo sapiens)
CBL binds to GRB2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Sprouty lures CBL away from EGFR (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
SPRY2 binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Negative regulation of FGFR2 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
SPRY2 binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Negative regulation of FGFR3 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
SPRY2 binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Negative regulation of FGFR4 signaling (Homo sapiens)
Spry regulation of FGF signaling (Homo sapiens)
CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
SPRY2 binds CBL (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Recruitment of CBL to KIT (Homo sapiens)
CBL [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
CBL binds TGFBR2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
CBL neddylates TGFBR2 (Homo sapiens)
CBL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22681 CBL
Gene Names
CBL, CBL2, RNF55
Chain
chain:1-906
Reference Genes
BioGPS Gene:867 CBL
COSMIC (genes):CBL CBL
CTD Gene:867 CBL
dbSNP Gene:867 CBL
ENSEMBL:ENSG00000110395 CBL
ENSEMBL_homo_sapiens_GENE:ENSG00000110395.8 CBL
HGNC:1541 CBL
KEGG Gene (Homo sapiens):867 CBL
Monarch:867 CBL
NCBI Gene:867 CBL
OMIM:165360 CBL
UCSC:P22681 CBL
Reference Transcript
RefSeq:NM_005188.3 CBL
Other Identifiers
11724807_at
11724808_at
11724809_at
11724810_at
1568191_PM_at
1568191_at
16732296
206607_PM_at
206607_at
225231_PM_at
225231_at
225234_PM_at
225234_at
229010_PM_at
229010_at
243475_PM_at
243475_at
3352072
3352073
3352074
3352075
3352079
3352087
3352088
3352089
3352091
3352092
3352093
3352094
3352095
3352097
3352098
3352102
3352104
3352105
3352106
3352108
3352109
3352110
3352111
3352112
3352113
3352114
3352115
3352116
3352117
3352118
3352129
34416_at
47569_at
51017_at
55605_at
68600_at
7944493
867
A_14_P115221
A_14_P135012
A_14_P135711
A_14_P200324
A_23_P339191
A_23_P53226
A_33_P3256033
GE59823
GE87401
GE88439
GO:0000209
GO:0001784
GO:0002376
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0005929
GO:0006511
GO:0006513
GO:0006974
GO:0007165
GO:0007166
GO:0008152
GO:0008584
GO:0010332
GO:0012501
GO:0014823
GO:0016020
GO:0016192
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0019221
GO:0019901
GO:0022414
GO:0023051
GO:0023052
GO:0030163
GO:0030424
GO:0030426
GO:0030971
GO:0032487
GO:0033574
GO:0035635
GO:0036120
GO:0036211
GO:0036312
GO:0042059
GO:0042594
GO:0042995
GO:0043066
GO:0043226
GO:0043303
GO:0045121
GO:0045296
GO:0045471
GO:0045742
GO:0046872
GO:0046875
GO:0048260
GO:0048471
GO:0048856
GO:0051865
GO:0051897
GO:0061630
GO:0070086
GO:0071456
GO:0140096
GO:1990090
GO:1990782
GO:2000583
HMNXSV003013983
Hs.196521.0.A1_3p_at
Hs.41324.0.A1_3p_at
Hs.90960.0.A1_3p_at
Hs.90960.0.A2_3p_at
Hs2.423675.1.A1_3p_at
ILMN_1716080
ILMN_2181968
PH_hs_0022112
PH_hs_0031180
TC11001089.hg
TC11002905.hg
X57110_s_at
g4885116_3p_at
Participates
as a component of
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
active FLT3:CBL [plasma membrane] (Homo sapiens)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Homo sapiens)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Homo sapiens)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Homo sapiens)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Homo sapiens)
CBL:SPRY1/2 [cytosol] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
CBL:GRB2 [cytosol] (Homo sapiens)
TGFBR2:CBL [plasma membrane] (Homo sapiens)
as an input of
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Active FLT3 binds to CBL (Homo sapiens)
Recruitment of CBL to KIT (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
SPRY2 binds CBL (Homo sapiens)
CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)
Sprouty lures CBL away from EGFR (Homo sapiens)
Binding of CBL to EGFR (Homo sapiens)
CBL binds to GRB2 (Homo sapiens)
PTK6 phosphorylates CBL (Homo sapiens)
CBL binds TGFBR2 (Homo sapiens)
as a candidate of
CBL:GRB2,CBL [cytosol] (Homo sapiens)
as an output of
CBL dissociates from ubiquitinated p-SPRY2 (Homo sapiens)
CBL neddylates TGFBR2 (Homo sapiens)
Other forms of this molecule
PolyUb,p-Y-CBL [cytosol]
CBL R420G [cytosol]
CBL R420Q [cytosol]
CBL Y371H [cytosol]
CBL H398Y [cytosol]
CBL P417A [cytosol]
CBL S376F [cytosol]
CBL E366_Q409del [cytosol]
CBL del366-477 [cytosol]
CBL R499L [cytosol]
CBL L380P [cytosol]
CBL L287R [cytosol]
CBL L380R [cytosol]
CBL G375P [cytosol]
CBL P417L [cytosol]
CBL H398Q [cytosol]
CBL P417R [cytosol]
CBL R499* [cytosol]
CBL H398R [cytosol]
CBL H398P [cytosol]
CBL G375fs*16 [cytosol]
CBL R420* [cytosol]
CBL H398D [cytosol]
CBL Y371C [cytosol]
CBL G375S [cytosol]
CBL Y371D [cytosol]
CBL Y371S [cytosol]
CBL P417S [cytosol]
CBL H398N [cytosol]
CBL R420P [cytosol]
CBL Y371N [cytosol]
CBL R499Q [cytosol]
CBL R420L [cytosol]
CBL P417H [cytosol]
p-Y-CBL [cytosol]
p-Y371-CBL [cytosol]
p-Y371-CBL [plasma membrane]
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
p-Y700,Y731,Y774-CBL [cytosol]
Inferred To
sli-1 [cytosol]
(Caenorhabditis elegans)
cbl [cytosol]
(Danio rerio)
Cbl [cytosol]
(Drosophila melanogaster)
Cbl [cytosol]
(Rattus norvegicus)
Ghost homologue of CBL [cytosol]
(Xenopus tropicalis)
CBL [cytosol]
(Bos taurus)
CBL [cytosol]
(Canis familiaris)
CBL [cytosol]
(Gallus gallus)
CBL [cytosol]
(Mus musculus)
CBL [cytosol]
(Plasmodium falciparum)
CBL [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_005179.2
OpenTargets
ENSG00000110395
GeneCards
P22681
HPA
ENSG00000110395-CBL
Ensembl
ENST00000264033
,
ENSG00000110395
,
ENSP00000264033
PRO
P22681
Pharos - Targets
P22681
Orphanet
19464
HMDB Protein
HMDBP07558
PDB
5O76
,
1B47
,
2CBL
,
5HKY
,
5HKZ
,
4GPL
,
4A4B
,
1YVH
,
2K4D
,
2OO9
,
3OB2
,
6O03
,
6XAR
,
6O02
,
3BUM
,
4A49
,
3OB1
,
2JUJ
,
3BUN
,
3PLF
,
1FBV
,
3BUW
,
2Y1M
,
3BUO
,
2Y1N
,
5J3X
,
4A4C
,
5HL0
,
7SIY
,
5HKX
,
3BUX
,
5HKW
Interactors (58)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.974
28
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.964
26
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.963
19
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.94
16
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.919
13
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.868
9
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.863
17
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.856
17
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.845
8
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.812
7
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.798
6
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.796
7
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.788
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.788
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.788
5
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.78
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.773
6
UniProt:P29353 SHC1
5
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
SHC1 [cytosol]
(R-HSA-74680)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
0.77
5
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.75
4
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.743
7
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.729
12
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.725
4
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.704
4
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.697
8
UniProt:O14492 SH2B2
2
SH2B2 [cytosol]
(R-HSA-112195)
p-Y629-SH2B2 [cytosol]
(R-HSA-112184)
0.656
7
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.621
4
UniProt:Q9C004 SPY4
0.611
9
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
0.611
4
UniProt:P43403 ZAP70
3
ZAP70 [cytosol]
(R-HSA-202397)
p-Y493-ZAP70 [cytosol]
(R-HSA-202368)
p-Y315,Y493-ZAP70 [cytosol]
(R-HSA-202252)
0.611
3
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
(R-MMU-9032530)
pFyn (420) [cytosol]
(R-MMU-420335)
pFyn(Y531) [cytosol]
(R-MMU-420350)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
0.591
3
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.591
9
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.57
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.564
2
UniProt:P55085 F2RL1
1
F2RL1(37-397) [plasma membrane]
(R-HSA-389418)
0.556
3
UniProt:P54253 ATX1
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:Q13196 Q13196
0.544
2
UniProt:Q96DA2 RAB39B
3
GGC-RAB39B [Golgi membrane]
(R-HSA-8877796)
GGC-RAB39B [cytosol]
(R-HSA-8874006)
RAB39B [cytosol]
(R-HSA-8873679)
0.527
2
UniProt:P28290 ITPI2
0.527
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
2
UniProt:Q96JA1 LRIG1
2
Ub-LRIG1 [plasma membrane]
(R-HSA-8875434)
LRIG1 [plasma membrane]
(R-HSA-197745)
0.524
2
UniProt:Q8IZP0-2 ABI1
0.524
3
UniProt:P08631-2 HCK
0.524
2
UniProt:F1SDV6
5
phospho-PLCG1 [plasma membrane]
(R-SSC-1169084)
phospho-PLCG1 [cytosol]
(R-SSC-202357)
PLCG1 [plasma membrane]
(R-SSC-167682)
PLCG1 [cytosol]
(R-SSC-202320)
phospho-PLCG1 [plasma membrane]
(R-SSC-167679)
0.524
2
UniProt:P06240 Lck
5
phospho-p-Y394-LCK [plasma membrane]
(R-MMU-8857940)
Lck [cytosol]
(R-MMU-539041)
phospho-p-Y505-LCK [plasma membrane]
(R-MMU-202159)
phospho-p-Y394-LCK [cytosol]
(R-MMU-202308)
LCK [cytosol]
(R-MMU-167609)
0.524
2
UniProt:P08487 PLCG1
0.518
3
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.499
2
UniProt:A0A0H3L6J6 A0A0H3L6J6
0.499
3
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.488
2
UniProt:P42229 STAT5A
4
STAT5A [nucleoplasm]
(R-HSA-9701901)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
STAT5A [cytosol]
(R-HSA-380747)
0.488
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.488
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.488
2
UniProt:P27986-2 PIK3R1
0.488
2
UniProt:P46108-2 CRK
0.488
2
UniProt:P26450 Pik3r1
5
p-Y-Pik3r1 [cytosol]
(R-MMU-9680631)
Pik3r1 [cytosol]
(R-MMU-3080572)
Pi3k-p85 alpha [cytosol]
(R-MMU-1295777)
Pik3r1 [cytosol]
(R-MMU-74789)
Pik3r1 [plasma membrane]
(R-MMU-198365)
0.462
2
UniProt:A9UF07 A9UF07
0.462
4
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