thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymidine or deoxyuridine with orthophosphate to form thymine or uracil and 2-deoxy-D-ribose 1-phosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).
Literature References
PubMed ID Title Journal Year
1590793 Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

Waltenberger, J, Miyazono, K, Usuki, K, Saras, J, Heldin, CH, Pierce, G, Thomason, A

Biochem Biophys Res Commun 1992
7284378 Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase

Bricaud, H, Desgranges, C, Rabaud, M, Razaka, G

Biochim Biophys Acta 1981
14725767 Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

McCall, EJ, Colls, JG, Timms, D, McAlister, MS, Barry, ST, Tucker, JA, Ernill, RJ, Norman, RA, Minshull, CA, McMiken, HH, Breed, J, Paterson, DS, Bate, M, Luke, RW, Pauptit, RA

Structure 2004
Catalyst Activity

pentosyltransferase activity of TYMP dimer [cytosol]

Orthologous Events
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