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CAMK4 [nucleoplasm]
Stable Identifier
R-HSA-112280
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CaMKIV, Calcium/calmodulin-dependent protein kinase type IV catalytic chain (EC 2.7.1.123) (CAM kinase-GR) (CaMK IV), Calcium/calmodulin-dependent protein kinase type IV catalytic chain , CAM kinase-GR, CaMK IV
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14161 GIT2
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
Calmodulin binds CAMK4 (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
Calmodulin binds CAMK4 (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
CAMK4 enters the nucleus (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
Calmodulin binds CAMK4 (Homo sapiens)
CAMK4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16566 CAMK4
Gene Names
CAMK4, CAMK, CAMK-GR, CAMKIV
Chain
chain:1-473
Reference Genes
BioGPS Gene:814 CAMK4
COSMIC (genes):CAMK4 CAMK4
CTD Gene:814 CAMK4
dbSNP Gene:814 CAMK4
ENSEMBL:ENSG00000152495 CAMK4
ENSEMBL_homo_sapiens_GENE:ENSG00000152495.11 CAMK4
HGNC:1464 CAMK4
KEGG Gene (Homo sapiens):814 CAMK4
Monarch:814 CAMK4
NCBI Gene:814 CAMK4
OMIM:114080 CAMK4
UCSC:Q16566 CAMK4
Reference Transcript
RefSeq:NM_001323375.1 CAMK4
RefSeq:NM_001744.5 CAMK4
RefSeq:NM_001323374.1 CAMK4
Other Identifiers
11739304_a_at
1421_at
1422_g_at
16987945
210349_PM_at
210349_at
229029_PM_at
229029_at
241871_PM_at
241871_at
2823882
2823883
2823884
2823885
2823886
2823904
2823911
2823912
2823916
2823922
2823923
2823932
2823933
2823936
2823937
2823938
2823939
2823940
2823941
2823942
2823943
2823944
2823945
2823946
2823947
2823959
2823961
2823963
2823964
2823965
2823966
2823967
2823969
2823971
2823973
2823975
2823977
2823978
2823979
33514_at
46191_at
53694_at
68195_at
8107307
814
A_14_P104648
A_23_P250347
D30742_at
GO:0000166
GO:0001650
GO:0002250
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0005516
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0007165
GO:0007616
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0033081
GO:0035556
GO:0036211
GO:0043011
GO:0043226
GO:0045670
GO:0045893
GO:0048856
GO:0050877
GO:0070062
GO:0106310
GO:0140096
HMNXSV003009172
Hs.190146.0.A1_3p_at
Hs.6187.0.A1_3p_at
ILMN_1767168
ILMN_2166582
PH_hs_0020794
PH_hs_0025799
TC05000521.hg
g407005_3p_at
Participates
as an output of
CAMK4 enters the nucleus (Homo sapiens)
as an input of
Calmodulin binds CAMK4 (Homo sapiens)
as a component of
CAMK4:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CAMK4 [cytosol]
p-T200-CAMK4 [nucleoplasm]
p-S12,S13,T200-CAMK4 [nucleoplasm]
Cross References
RefSeq
NP_001310304.1
,
NP_001310303.1
,
NP_001735.1
ZINC - World Drugs
KCC4_HUMAN
Guide to Pharmacology - Targets
1955
OpenTargets
ENSG00000152495
ZINC - FDA approved
KCC4_HUMAN
ZINC - Substances
KCC4_HUMAN
ZINC target
Q16566
ZINC - Biogenic
KCC4_HUMAN
PRO
Q16566
PDB
2W4O
ZINC - Investigational
KCC4_HUMAN
HPA
ENSG00000152495-CAMK4
GeneCards
Q16566
Ensembl
ENSP00000422634
,
ENSP00000282356
,
ENST00000512453
,
ENSG00000152495
,
ENST00000282356
Pharos - Targets
Q16566
ZINC - Predictions - Purchasable
KCC4_HUMAN
HMDB Protein
HMDBP01381
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.527
2
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.527
2
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