Reactome | Neurotransmitter release cycle

Neurotransmitter release cycle

Stable Identifier

R-HSA-112310

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.

Literature References

PubMed ID	Title	Journal	Year
17880890	The neurotransmitter cycle and quantal size Edwards, RH	Neuron	2007
15217342	The synaptic vesicle cycle Südhof, TC	Annu Rev Neurosci	2004
16865347	Molecular organization of the presynaptic active zone Schoch, S, Gundelfinger, ED	Cell Tissue Res	2006
16819626	Vesicle pools, docking, priming, and release Rettig, J, Becherer, U	Cell Tissue Res	2006