Inactivation of MAP2K1 by CDK1

Stable Identifier
R-HSA-112342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Inactivation of MAP2K1 by CDK1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 2 molecules of 'ATP', and 1 molecule of 'MEK1' are present. At the end of this reaction, 1 molecule of 'phospho_MEK1', and 2 molecules of 'ADP' are present.
This reaction takes place in the 'cytosol' and is mediated by the 'protein serine/threonine kinase activity' of 'phospho-Cdc2 (Thr 161)'(Shah et al.2003 ).

Literature References
PubMed ID Title Journal Year
12586835 Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2

Ghosh, S, Shah, OJ, Hunter, T

J. Biol. Chem. 2003
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T161-CDK1 [cytosol]

Physical Entity
p-T161-CDK1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Inactivation of MAP2K1 by CDK1 (Bos taurus)
Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)
Inactivation of MAP2K1 by CDK1 (Danio rerio)
Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)
Inactivation of MAP2K1 by CDK1 (Gallus gallus)
Inactivation of MAP2K1 by CDK1 (Mus musculus)
Inactivation of MAP2K1 by CDK1 (Rattus norvegicus)
Created
Charalambous, M  (2004-04-29)
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